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Gene Review:

UPS2 - ureide permease 2

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA UREIDE PERMEASE 2, ATUPS2, T4M8.3, T4M8_3

Schmidt, A. et al., Schmidt, A. et al.

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High impact information on UPS2

UPS1 and UPS2 from Arabidopsis mediate high affinity transport of uracil and 5-fluorouracil [1].
Arabidopsis ups2 insertion mutants and ups1 lines, in which transcript levels were reduced by post-transcriptional gene silencing, are more tolerant to 5-fluorouracil as compared with wild type plants [1].
Consistent with a function during germination and early seedling development, AtUPS1 expression is transiently induced during the early stages of seedling development followed by up-regulation of AtUPS2 expression [1].

Biological context of UPS2

A detailed analysis of the substrate specificities of two members of the AtUPS family shows that AtUPS1 and AtUPS2 mediate high affinity uracil and 5-fluorouracil (a toxic uracil analogue) transport when expressed in yeast and Xenopus oocytes [1].

Associations of UPS2 with chemical compounds

When expressed in yeast, AtUPS5l mediates cellular import of cyclic purine degradation products and pyrimidines similarly to AtUPS1 and AtUPS2, but differences in transport efficiencies were observed [2].

References

UPS1 and UPS2 from Arabidopsis mediate high affinity transport of uracil and 5-fluorouracil. Schmidt, A., Su, Y.H., Kunze, R., Warner, S., Hewitt, M., Slocum, R.D., Ludewig, U., Frommer, W.B., Desimone, M. J. Biol. Chem. (2004) [Pubmed]
Comparative studies on Ureide Permeases in Arabidopsis thaliana and analysis of two alternative splice variants of AtUPS5. Schmidt, A., Baumann, N., Schwarzkopf, A., Frommer, W.B., Desimone, M. Planta (2006) [Pubmed]

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