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Gene Review

HPT1  -  homogentisate phytyltransferase 1

Arabidopsis thaliana

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Disease relevance of HPT1


High impact information on HPT1

  • Surprisingly subtle differences were observed between the tocopherol-deficient vte2 mutant and the wild type during high-light, salinity, and drought stresses [2].
  • Both biochemical and transcriptional analyses of vte2 seedlings indicate that nonenzymatic lipid peroxidation plays a significant role in modulating plant defense responses [3].
  • In the absence of pathogens, the phytoalexin camalexin accumulated in vte2 seedlings to levels 100-fold higher than in wild-type or vte1 seedlings [3].
  • However, vte2, and to a lesser extent vte1, exhibited dramatic phenotypes under low temperature (i.e., increased anthocyanin levels and reduced growth and seed production) [2].
  • The rapid reduction in photoassimilate export in vte2 coincides with callose deposition exclusively in phloem parenchyma transfer cell walls adjacent to the companion cell/sieve element complex [2].

Chemical compound and disease context of HPT1


Biological context of HPT1

  • Compared with the wild type, vte1 and vte2 had reduced rates of photoassimilate export as early as 6 h into low-temperature treatment, increased soluble sugar levels by 60 h, and increased starch and reduced photosynthetic electron transport rate by 14 d [2].
  • In this study, we describe the identification of conserved amino acid sequences within VTE2 and HGGT and the application of these conserved sequences for a motif analysis resulting in the discovery of a VTE2-paralog in the Arabidopsis genome [4].

Associations of HPT1 with chemical compounds


  1. Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis. Collakova, E., DellaPenna, D. Plant Physiol. (2001) [Pubmed]
  2. Tocopherols play a crucial role in low-temperature adaptation and Phloem loading in Arabidopsis. Maeda, H., Song, W., Sage, T.L., Dellapenna, D. Plant Cell (2006) [Pubmed]
  3. Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants. Sattler, S.E., Mène-Saffrané, L., Farmer, E.E., Krischke, M., Mueller, M.J., Dellapenna, D. Plant Cell (2006) [Pubmed]
  4. Identification and characterization of an Arabidopsis homogentisate phytyltransferase paralog. Venkatesh, T.V., Karunanandaa, B., Free, D.L., Rottnek, J.M., Baszis, S.R., Valentin, H.E. Planta (2006) [Pubmed]
  5. Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Collakova, E., DellaPenna, D. Plant Physiol. (2003) [Pubmed]
  6. Vitamin E protects against photoinhibition and photooxidative stress in Arabidopsis thaliana. Havaux, M., Eymery, F., Porfirova, S., Rey, P., Dörmann, P. Plant Cell (2005) [Pubmed]
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