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Gene Review: 

Dync1li2  -  dynein, cytoplasmic 1 light intermediate...

Rattus norvegicus

Synonyms: Cytoplasmic dynein 1 light intermediate chain 2, Dncli2, Dynein light intermediate chain 2, cytosolic, LIC-2, LIC53/55, ...
 
 
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High impact information on Dncli2

  • Here we report the cloning of rat LIC1, which is approximately 75% homologous to rat LIC2 and also contains a P-loop consensus sequence [1].
  • Two of these, lic1 and lic2, contain multiple open-reading frames (ORFs) and include tandem repeats of the tetramer CAAT within and at the 5' end of the coding region of the first ORF in each locus [2].
  • The ribonucleotide probe, referred to the 5' end of open reading frame (6-515 nucleotids) of cytoplasmic dynein light-intermediate chain 53/55 (LIC-2) of the rat brain (Hughes et al., 1995. J. Cell Sci., 108: 17-24), was used [3].
 

Analytical, diagnostic and therapeutic context of Dncli2

  • The primers for RT-PCR were designed according to LIC-2 (LIC 53/55) (15) [4].

References

  1. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. Tynan, S.H., Purohit, A., Doxsey, S.J., Vallee, R.B. J. Biol. Chem. (2000) [Pubmed]
  2. Molecular biology of phase-variable lipopolysaccharide biosynthesis by Haemophilus influenzae. Maskell, D.J., Szabo, M.J., Butler, P.D., Williams, A.E., Moxon, E.R. J. Infect. Dis. (1992) [Pubmed]
  3. Localization of cytoplasmic dynein light-intermediate chain mRNA in the rat testis using in situ hybridization. Maeda, S., Nam, S.Y., Fujisawa, M., Nakamuta, N., Ogawa, K., Kurohmaru, M., Hayashi, Y. Cell Struct. Funct. (1998) [Pubmed]
  4. Characterization of cytoplasmic dynein light-intermediate chain isoforms in rat testis. Maeda, S., Nam, S.Y., Fujisawa, M., Nakamuta, N., Ogawa, K., Kurohmaru, M., Hayashi, Y. Cell Struct. Funct. (1998) [Pubmed]
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