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Gene Review

Grm7  -  glutamate receptor, metabotropic 7

Rattus norvegicus

Synonyms: Gprc1g, Metabotropic glutamate receptor 7, Mglur7, mGluR7
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Disease relevance of Grm7


High impact information on Grm7


Chemical compound and disease context of Grm7

  • Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons [6].

Biological context of Grm7


Anatomical context of Grm7


Associations of Grm7 with chemical compounds

  • To gain further insight into the intracellular signaling mechanisms of mGluR7, with the aid of glutathione S-transferase fusion affinity chromatography, we attempted to identify proteins that interact with the intracellular carboxyl terminus of mGluR7 [10].

Regulatory relationships of Grm7


Other interactions of Grm7

  • Consistent with previous studies, one receptor subtype is an L-AP4-sensitive receptor that is pharmacologically similar to mGluR4 or mGluR7 [15].
  • A small number of bipolar cells were also labelled for mGluR5 and mGluR7 [1].
  • The mGluR1, mGluR4 and mGluR7 receptors may be involved in the processing of somatosensory information because they are expressed in nuclei that receive direct sensory input [13].
  • Similar decreases of mGluR7 mRNA expression in the VB and Po were found at all time points, while mGluR3 mRNA expression was bilaterally increased in the reticular thalamic nucleus (Rt) [16].
  • Distribution analysis for mGluR7 and mGluR8 isoforms revealed that the two splice variants are generally coexpressed in the same brain areas [8].

Analytical, diagnostic and therapeutic context of Grm7


  1. Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells. Hartveit, E., Brandstätter, J.H., Enz, R., Wässle, H. Eur. J. Neurosci. (1995) [Pubmed]
  2. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Shigemoto, R., Kulik, A., Roberts, J.D., Ohishi, H., Nusser, Z., Kaneko, T., Somogyi, P. Nature (1996) [Pubmed]
  3. Long-term depression in hippocampal interneurons: joint requirement for pre- and postsynaptic events. Laezza, F., Doherty, J.J., Dingledine, R. Science (1999) [Pubmed]
  4. Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains. Stowell, J.N., Craig, A.M. Neuron (1999) [Pubmed]
  5. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. Bradley, S.R., Levey, A.I., Hersch, S.M., Conn, P.J. J. Neurosci. (1996) [Pubmed]
  6. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Li, J.L., Ohishi, H., Kaneko, T., Shigemoto, R., Neki, A., Nakanishi, S., Mizuno, N. Neurosci. Lett. (1996) [Pubmed]
  7. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N., Nakanishi, S. J. Biol. Chem. (1994) [Pubmed]
  8. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. Corti, C., Restituito, S., Rimland, J.M., Brabet, I., Corsi, M., Pin, J.P., Ferraguti, F. Eur. J. Neurosci. (1998) [Pubmed]
  9. Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. Brandstätter, J.H., Koulen, P., Kuhn, R., van der Putten, H., Wässle, H. J. Neurosci. (1996) [Pubmed]
  10. A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. Nakajima, Y., Yamamoto, T., Nakayama, T., Nakanishi, S. J. Biol. Chem. (1999) [Pubmed]
  11. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Saugstad, J.A., Kinzie, J.M., Mulvihill, E.R., Segerson, T.P., Westbrook, G.L. Mol. Pharmacol. (1994) [Pubmed]
  12. Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability. Gereau, R.W., Conn, P.J. J. Neurophysiol. (1995) [Pubmed]
  13. Differential distribution of metabotropic glutamate receptor subtype mRNAs in the thalamus of the rat. Lourenço Neto, F., Schadrack, J., Berthele, A., Zieglgänsberger, W., Tölle, T.R., Castro-Lopes, J.M. Brain Res. (2000) [Pubmed]
  14. Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. Ohishi, H., Akazawa, C., Shigemoto, R., Nakanishi, S., Mizuno, N. J. Comp. Neurol. (1995) [Pubmed]
  15. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. Gereau, R.W., Conn, P.J. J. Neurosci. (1995) [Pubmed]
  16. Expression of metabotropic glutamate receptors mRNA in the thalamus and brainstem of monoarthritic rats. Lourenço Neto, F., Schadrack, J., Platzer, S., Zieglgänsberger, W., Tölle, T.R., Castro-Lopes, J.M. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  17. Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system. Tong, Q., Kirchgessner, A.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  18. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat. Ohishi, H., Nomura, S., Ding, Y.Q., Shigemoto, R., Wada, E., Kinoshita, A., Li, J.L., Neki, A., Nakanishi, S., Mizuno, N. Neurosci. Lett. (1995) [Pubmed]
  19. Development of a functional reporter gene HTS assay for the identification of mGluR7 modulators. Terstappen, G.C., Giacometti, A., Ballini, E., Aldegheri, L. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. (2000) [Pubmed]
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