Disease relevance of Jundm2

• Northern blot analysis showed Jdp2 to be alternatively spliced in various normal tissues as well as MLV-induced lymphomas [1].
• The element activated by both TIF and ICP0 was mapped to a 229-base-pair fragment which also contains an HPV-18 epithelial cell-preferred enhancer [2].
• A feature of the cascade regulation of herpes simplex virus 1 gene expression in productive infection is that the first genes to be expressed, the alpha genes, are transactivated by a structural component of the virion designated as the alpha transinducing factor (alpha TIF) [3].
• For the C3H/TIF induction of ischemia for up to 6 h resulted in no significant growth delay provided the tumours were kept at room temperature [4].
• In general, amyloidosis in CD-1 mice, was higher in comparison with B6C3F (cross between C57BL/C6 NCRLB and C3H/HEN NCRLB, (bred by Charles River), CFLP strain (hysterectomy derived strain of Swiss origin) and MAGF: TIF (SPF) [5].

High impact information on Jundm2

• RNAi-induced loss of p53 overcomes proliferation arrest and apoptosis in response to TIF-IA ablation [6].
• In MEFs, Cre-mediated depletion of TIF-IA leads to disruption of nucleoli, cell cycle arrest, upregulation of p53, and induction of apoptosis [6].
• TIF-IA-/- embryos die before or at embryonic day 9.5 (E9.5), displaying retardation of growth and development [6].
• The metallothionein promoter inserted into the viral genome was shown to be expressed, and alpha TIF mRNA was detected by in situ hybridization of sections of trigeminal ganglia of mice infected with R6003, both untreated and those given cadmium injections [3].
• In this study, we have tested the hypothesis that latent infection of sensory neurons results from the failure of alpha TIF, a tegument protein, to be transported from the nerve endings to the nucleus of the sensory neuron [3].

Biological context of Jundm2

• Tumor model-specific proviral insertional mutagenesis of the Fos/Jdp2/Batf locus [1].
• Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2 [7].

Anatomical context of Jundm2

• Retroviral activation of the AP-1/ATF super family member Jdp2 was recently reported to be a common event in M-MLV-induced T cell lymphoma in p27-null C57x129 mice as compared to wild type-inoculated mice but has not been found important in other models [1].
• In another series of experiments, transgenic mice expressing the metallothionein-driven alpha TIF did not differ from nontransgenic siblings with respect to the incidence of latent virus in trigeminal ganglia [3].
• Both HSV-1 TIF and ICP0 activated HPV-18 expression; however, activation by TIF was observed only in epithelial cells, while ICP0 stimulated expression in a wide variety of cells [2].

Other interactions of Jundm2

• A novel integration cluster between Jdp2 and Batf apparently did not influence the expression level of either gene, underscoring the importance of addressing expression effects to identify target genes of insertion [1].

References