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Gene Review:

GRV2 - gravitropism defective 2

Arabidopsis thaliana

Synonyms: F12C20.7, F12C20_7, GRAVITROPISM DEFECTIVE 2, KAM2, KATAMARI2

Silady, R.A. et al., Silady, R.A. et al.

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High impact information on GRV2

The GRV2 gene encodes a 277-kD polypeptide that is 42% similar to the Caenorhabditis elegans RME-8 protein, which is required for endocytosis [1].
The gravitropism defective 2 (grv2) mutants of Arabidopsis show reduced shoot phototropism and gravitropism [1].

Associations of GRV2 with chemical compounds

The GRV2-positive endosomes were sensitive to Wortmannin but not brefeldin A (BFA), consistent with GRV2 operating late in the endocytic pathway, prior to delivery of vesicles to the central vacuole [2].

References

The gravitropism defective 2 mutants of Arabidopsis are deficient in a protein implicated in endocytosis in Caenorhabditis elegans. Silady, R.A., Kato, T., Lukowitz, W., Sieber, P., Tasaka, M., Somerville, C.R. Plant Physiol. (2004) [Pubmed]
The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow. Silady, R.A., Ehrhardt, D.W., Jackson, K., Faulkner, C., Oparka, K., Somerville, C.R. Plant J. (2008) [Pubmed]

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AgaP_AGAP005771	Anopheles gambiae str. PEST
DNAJC13	Bos taurus
rme-8	Caenorhabditis elegans
DNAJC13	Canis lupus familiaris
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Dnajc13	Mus musculus
Os10g0575200	Oryza sativa Japonica Group
DNAJC13	Pan troglodytes
Dnajc13	Rattus norvegicus
dnajc13	Xenopus (Silurana) tropicalis

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