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Gene Review

LOS2  -  bifunctional enolase 2/transcriptional...

Arabidopsis thaliana

Synonyms: ENO2, ENOC, ENOLASE 2, F1O11.16, F1O11_16, ...
 
 
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High impact information on LOS2

  • STZ/ZAT10 expression is induced rapidly and transiently by cold in the wild type, and this induction is stronger and more sustained in the los2 mutant [1].
  • In animal cells, enolase has also been known to function as a transcription factor that represses the expression of c-myc by binding to the c-myc gene promoter [1].
  • Four of these enzymes (glyceraldehyde-3-P dehydrogenase, aldolase, phosphoglycerate mutase, and enolase) were also identified in an intermembrane space/outer mitochondrial membrane fraction [2].
  • The association of glycolytic enzymes with mitochondria was confirmed in vivo by the expression of enolase- and aldolase-yellow fluorescent protein fusions in Arabidopsis protoplasts [2].
  • Other proteins identified include annexin, glyoxalase I, enolase and two lipoxygenases, the sequences of which are highly conserved among potato variants [3].
 

Biological context of LOS2

  • The full-length cDNA of C. bursa-pastoris LOS2 gene (designated as Cblos2) was 1694 bp containing a 1332 bp open reading frame (ORF) encoding a 444 amino acid protein [4].
 

Analytical, diagnostic and therapeutic context of LOS2

References

  1. LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase. Lee, H., Guo, Y., Ohta, M., Xiong, L., Stevenson, B., Zhu, J.K. EMBO J. (2002) [Pubmed]
  2. Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells. Giegé, P., Heazlewood, J.L., Roessner-Tunali, U., Millar, A.H., Fernie, A.R., Leaver, C.J., Sweetlove, L.J. Plant Cell (2003) [Pubmed]
  3. Patatins, Kunitz protease inhibitors and other major proteins in tuber of potato cv. Kuras. Bauw, G., Nielsen, H.V., Emmersen, J., Nielsen, K.L., Jørgensen, M., Welinder, K.G. FEBS J. (2006) [Pubmed]
  4. Molecular cloning of a novel LOS2 gene from Capsella bursa-pastoris. Liu, S.X., Wang, X.L., Yang, J.S., Fan, Z.Q., Sun, X.F., Wang, X.R., Tang, K.X. Yi Chuan Xue Bao (2005) [Pubmed]
 
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