High impact information on FHY1

• FHY1: a phytochrome A-specific signal transducer [1].
• In addition, FHY1 transcript levels are regulated by light, and by the product of FHY3, another gene implicated in FR signaling [1].
• Genetic analysis indicated that FIN219 interacts closely with another phytochrome A signaling component, FHY1 [2].
• Lines in which FHL function was abolished by insertional mutagenesis or attenuated by RNAi-mediated suppression displayed a weaker hyposensitivity to continuous FR than fhy1 null mutants and most reported phyA signaling mutants [3].
• Together with the results from global expression analysis, our findings point to an important role of FHY1 in phyA signaling through its nuclear translocation and induction of gene expression [4].

Biological context of FHY1

• High intensity far-red light provides a way to specifically assess the role of phyA in this process and was used to isolate phyA-signaling intermediates. fhy1 and pat3 (renamed fhy1-3) are independently isolated alleles of a gene encoding a phyA signal transduction component [4].
• A 2,248-bp genomic fragment of the PAT3 locus can complement the pat3 mutant phenotype [5].

Anatomical context of FHY1

• FHY1 and FHL Act Together to Mediate Nuclear Accumulation of the Phytochrome A Photoreceptor [6].

Regulatory relationships of FHY1

• Arabidopsis FHY1 protein stability is regulated by light via phytochrome A and 26S proteasome [7].

Other interactions of FHY1

• Among the phyA downstream signaling components, Far-red Elongated Hypocotyl 1 (FHY1) is a genetically defined positive regulator of photomorphogenesis in far-red light [7].
• fhy1 defines a branch point in phytochrome A signal transduction pathways for gene expression [8].

Analytical, diagnostic and therapeutic context of FHY1

• Here we describe the molecular cloning and functional characterization of Arabidopsis FHY1 [1].
• Real-time PCR indicates that in FR, FHY1 transcripts are approximately 15-fold more abundant than FHL transcripts [3].

References