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Gene Review:

SCAR2 - WAVE complex SCAR2

Arabidopsis thaliana

Synonyms: ATSCAR2, DIS3, IRREGULAR TRICHOME BRANCH1, IRREGULAR TRICHOME BRANCH1, ITB1, ...

Zhang, X. et al., Basu, D. et al.

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High impact information on ITB1

Positional cloning of the ITB1 gene showed that it encodes SCAR2, an Arabidopsis protein related to Scar/WAVE [1].
Here, we show that itb1 mutants display cell expansion defects similar to those reported for the distorted class of trichome mutants, including disruption of actin and microtubule organization [1].
DISTORTED3/SCAR2 is a putative arabidopsis WAVE complex subunit that activates the Arp2/3 complex and is required for epidermal morphogenesis [2].

References

IRREGULAR TRICHOME BRANCH1 in Arabidopsis encodes a plant homolog of the actin-related protein2/3 complex activator Scar/WAVE that regulates actin and microtubule organization. Zhang, X., Dyachok, J., Krishnakumar, S., Smith, L.G., Oppenheimer, D.G. Plant Cell (2005) [Pubmed]
DISTORTED3/SCAR2 is a putative arabidopsis WAVE complex subunit that activates the Arp2/3 complex and is required for epidermal morphogenesis. Basu, D., Le, J., El-Essal, S.e.l.-.D., Huang, S., Zhang, C., Mallery, E.L., Koliantz, G., Staiger, C.J., Szymanski, D.B. Plant Cell (2005) [Pubmed]

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