Disease relevance of ERD15

• PCI6 and PCI243 share a conserved amino acid domain (SxLnpnApxFxP) in common with human PABP-CT interactors, and with Arabidopsis ERD15 (early-responsive to dehydration) [1].

High impact information on ERD15

• A dehydration-induced NAC protein, RD26, is involved in a novel ABA-dependent stress-signaling pathway [2].
• The dehydration-induced expression is not impaired in aba-1, abi1-1, abi2-1, and abi3-1 mutants, suggesting that the dehydration-induced expression of the RPK1 gene is ABA-independent [3].
• Effects of COR6.6 and COR15am polypeptides encoded by COR (cold-regulated) genes of Arabidopsis thaliana on dehydration-induced phase transitions of phospholipid membranes [4].
• Neither COR6.6 nor COR15am altered the dehydration-induced gel lamellar --> fluid lamellar phase transition temperature of either dipalmitoylphosphatidylcholine or dioleoylphosphatidylcholine (DOPC) [4].
• Deletion analysis and point mutations indicate that presence of this domain is necessary for the interaction, and tests with ERD15 demonstrate that it is predictive of interaction [1].

Associations of ERD15 with chemical compounds

• These results suggest that dehydration-induced accumulation of free leucine and isoleucine is achieved independent of ABA [5].
• In contrast to the wild-type plants, dehydration-induced accumulation of proline was highly suppressed in the aba2-2 mutant plants while that of leucine and isoleucine accumulated [5].

Other interactions of ERD15

• Two proteins, which we named CID1 and CID7, were initially isolated in a two-hybrid screen, and eleven more were predicted to be present in the Arabidopsis proteome and eleven in the rice proteome [6].
• In addition, hypergravity increased the expression levels of genes encoding CCR1 and ERD15, which were shown to take part in the signaling pathway of environmental stimuli such as temperature and water, and those of the alpha-tubulin gene [7].
• ERD6, a cDNA clone for an early dehydration-induced gene of Arabidopsis, encodes a putative sugar transporter [8].

Analytical, diagnostic and therapeutic context of ERD15

• Pulse-modulation fluorometry was employed to characterize one line (denoted Lsr1(-)) that exhibited an approximately 50% reduction in NPQ compared to the wild type (WT) [9].

References