The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

JAR1  -  jasmonic acid-amido synthetase JAR1

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of JAR1


High impact information on JAR1

  • Genetic analysis indicated that FIN219 interacts closely with another phytochrome A signaling component, FHY1 [2].
  • Molecular characterization of FIN219 indicated that it encodes a cytoplasmic localized protein highly similar to the GH3 family of proteins and its expression is rapidly induced by auxin [2].
  • In contrast to its loss-of-function mutant phenotype, overexpression of FIN219 results in a far-red-specific hyperphotomorphogenic response [2].
  • Jasmonate response locus JAR1 and several related Arabidopsis genes encode enzymes of the firefly luciferase superfamily that show activity on jasmonic, salicylic, and indole-3-acetic acids in an assay for adenylation [3].
  • Analysis of fold predictions for this protein family suggested that JAR1 might belong to the acyl adenylate-forming firefly luciferase superfamily [3].

Biological context of JAR1

  • This suggests that EIN2 function is epistatic to JAR1, and that the JAR1-dependent JA pathway halts oxidative cell death by directly inhibiting ET signaling [1].
  • Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells [4].
  • The jasmonate (JA)-insensitive mutant jar1 showed normal induction kinetics for both GSTs [5].

Associations of JAR1 with chemical compounds


Other interactions of JAR1

  • Further phenotypic analyses of this new mutation, named fin219, suggested that it defines a novel phytochrome A signaling component [2].
  • Furthermore, the response to far-red light depended on functional FHY1 but not on FIN219 and FHY3 [8].

Analytical, diagnostic and therapeutic context of JAR1

  • Thin-layer chromatography and gas chromatography-mass spectrometry (GC-MS) analysis of products produced in vitro by recombinant JAR1 demonstrated that this enzyme forms JA-amido conjugates with several amino acids, including JA-Ile [9].


  1. Mutual antagonism of ethylene and jasmonic acid regulates ozone-induced spreading cell death in Arabidopsis. Tuominen, H., Overmyer, K., Keinänen, M., Kollist, H., Kangasjärvi, J. Plant J. (2004) [Pubmed]
  2. FIN219, an auxin-regulated gene, defines a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development. Hsieh, H.L., Okamoto, H., Wang, M., Ang, L.H., Matsui, M., Goodman, H., Deng, X.W. Genes Dev. (2000) [Pubmed]
  3. Jasmonate response locus JAR1 and several related Arabidopsis genes encode enzymes of the firefly luciferase superfamily that show activity on jasmonic, salicylic, and indole-3-acetic acids in an assay for adenylation. Staswick, P.E., Tiryaki, I., Rowe, M.L. Plant Cell (2002) [Pubmed]
  4. Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure. Suhita, D., Raghavendra, A.S., Kwak, J.M., Vavasseur, A. Plant Physiol. (2004) [Pubmed]
  5. The rapid induction of glutathione S-transferases AtGSTF2 and AtGSTF6 by avirulent Pseudomonas syringae is the result of combined salicylic acid and ethylene signaling. Lieberherr, D., Wagner, U., Dubuis, P.H., Métraux, J.P., Mauch, F. Plant Cell Physiol. (2003) [Pubmed]
  6. Downy mildew (Peronospora parasitica) resistance genes in Arabidopsis vary in functional requirements for NDR1, EDS1, NPR1 and salicylic acid accumulation. McDowell, J.M., Cuzick, A., Can, C., Beynon, J., Dangl, J.L., Holub, E.B. Plant J. (2000) [Pubmed]
  7. Methyl jasmonate inhibition of root growth and induction of a leaf protein are decreased in an Arabidopsis thaliana mutant. Staswick, P.E., Su, W., Howell, S.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Overexpression of the heterotrimeric G-protein alpha-subunit enhances phytochrome-mediated inhibition of hypocotyl elongation in Arabidopsis. Okamoto, H., Matsui, M., Deng, X.W. Plant Cell (2001) [Pubmed]
  9. The oxylipin signal jasmonic acid is activated by an enzyme that conjugates it to isoleucine in Arabidopsis. Staswick, P.E., Tiryaki, I. Plant Cell (2004) [Pubmed]
WikiGenes - Universities