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Gene Review:

UVR3 - (6-4)DNA photolyase

Arabidopsis thaliana

Synonyms: 6-4 PHOTOLYASE, UV REPAIR DEFECTIVE 3

Boccalandro, H.E. et al., Jiang, C.Z. et al., Liu, Z. et al., Nakajima, S. et al.

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Disease relevance of UVR3

This cloned gene produces a protein with 6-4 photolyase activity when expressed in Escherichia coli [1].

High impact information on UVR3

We describe the isolation and characterization of two new classes of mutants of Arabidopsis, termed uvr2 and uvr3, that are defective in the photoreactivation of CPDs and 6-4 products, respectively [2].

Biological context of UVR3

The enhancing effect of low doses of UV-B on cotyledon opening in uvr1 uvr2 and uvr1 uvr3 mutants, deficient in DNA repair, was similar to that found in the wild type, suggesting that this effect of UV-B was not elicited by signals derived from UV-B-induced DNA lesions (cyclobutane pyrimidine dimers and 6-4 photoproducts) [3].

Associations of UVR3 with chemical compounds

UVR2 and UVR3 products were previously identified as photolyases that remove UV-induced pyrimidine dimers in the presence of visible light [4].

References

Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana. Nakajima, S., Sugiyama, M., Iwai, S., Hitomi, K., Otoshi, E., Kim, S.T., Jiang, C.Z., Todo, T., Britt, A.B., Yamamoto, K. Nucleic Acids Res. (1998) [Pubmed]
Photorepair mutants of Arabidopsis. Jiang, C.Z., Yee, J., Mitchell, D.L., Britt, A.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Ultraviolet B radiation enhances a phytochrome-B-mediated photomorphogenic response in Arabidopsis. Boccalandro, H.E., Mazza, C.A., Mazzella, M.A., Casal, J.J., Ballaré, C.L. Plant Physiol. (2001) [Pubmed]
Repair of UV damage in plants by nucleotide excision repair: Arabidopsis UVH1 DNA repair gene is a homolog of Saccharomyces cerevisiae Rad1. Liu, Z., Hossain, G.S., Islas-Osuna, M.A., Mitchell, D.L., Mount, D.W. Plant J. (2000) [Pubmed]

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