Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TOP6B - DNA topoisomerase 6 subunit B

Arabidopsis thaliana

Synonyms: ATTOP6B, BIN3, BRASSINOSTEROID INSENSITIVE 3, ELONGATED HYPOCOTYL 6, HYP6, ...

Yin, Y. et al.

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High impact information on ATTOP6B

These results suggest that BIN3 and BIN5 may constitute an Arabidopsis topoisomerase VI that modulates expression of many genes, including those regulated by BRs [1].
In the dark, bin3 or bin5 seedlings are de-etiolated with short hypocotyls and open cotyledons [1].

Biological context of ATTOP6B

Two dwarf mutants named bin3 and bin5 with identical phenotypes to each other display some characteristics of BR mutants and are partially insensitive to exogenously applied BRs [1].

Analytical, diagnostic and therapeutic context of ATTOP6B

Furthermore, microarray analysis of the expression of about 5500 genes in bin3 or bin5 mutants indicates that about 321 genes are down-regulated in both of the mutants, including 18 of 30 BR-induced genes [1].

References

A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development. Yin, Y., Cheong, H., Friedrichsen, D., Zhao, Y., Hu, J., Mora-Garcia, S., Chory, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]

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