Gene Review:
MAD2 - mitotic spindle checkpoint protein MAD2
Arabidopsis thaliana
Synonyms:
AtMAD2, MITOTIC ARREST-DEFICIENT 2
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High impact information on AT3G25980
- MAD2 locates at spindle-unattached kinetochores during prophase and dissolves from spindle-attached kinetochores towards metaphase [1].
- We generated antibodies against the polypeptides with amino acid sequences derived from the cDNA sequences of the wheat MAD2 homologues [1].
- Thus, the wheat MAD2 protein could be a good marker for the functional kinetochores of metaphase chromosomes in wheat [1].
- Using these antibodies, we found MAD2 in wheat root-tip cells to change in location and amount through the cell cycle, similar to those reported for human MAD2 [1].
References
- Characterization of the genes encoding for MAD2 homologues in wheat. Kimbara, J., Endo, T.R., Nasuda, S. Chromosome Res. (2004) [Pubmed]
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