High impact information on RGS1

• The roles of AtRGS1 proteins in Arabidopsis seed germination and their possible interactions with sugars and abscisic acid (ABA) were investigated in this study [1].
• Hypersensitive responses of seed germination to both Glc and ABA were also observed in the overexpressor of AtRGS1 [1].
• Using seeds that carry a null mutation in the genes encoding RGS protein (AtRGS1) and the alpha-subunit (AtGPA1) of the G protein in Arabidopsis (named rgs1-2 and gpa1-3, respectively), our genetic evidence proved the involvement of the AtRGS1 protein in the modulation of seed germination [1].
• Reverse transcription-PCR (RT-PCR) results indicated that RGS1 overexpresssion significantly stimulated the expression of NCED and ABA2, that encode two key enzymes catalysing ABA biosynthesis [2].
• In the experiments reported here, the overexpression approach was used to present evidence that RGS1 protein plays critical roles in plant development and in modulating abscisic acid (ABA) and drought stress signal transduction [2].

Biological context of RGS1

• AtRGS1 modulates plant cell proliferation [3].
• We have identified a novel additional component of heterotrimeric G-protein signaling in the A. thaliana genome, regulator of G-protein signaling-1 (AtRGS1) [4].
• Expression of AtRGS1 complemented the pheromone supersensitivity phenotype of a yeast RGS mutant, sst2Delta [5].

Associations of RGS1 with chemical compounds

• Atrgs1 mutants are insensitive to glucose and less sensitive to fructose and sucrose, suggesting that sugar signaling in Arabidopsis involves AtRGS1 [3].

Other interactions of RGS1

• This protein has the predicted topology and structure of a G-protein-coupled receptor in that it contains seven transmembrane domains, but AtRGS1 also contains a unique C-terminal extension, namely a regulator of G-protein signaling domain (RGS box) [4].

References