The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IVD  -  isovaleryl-CoA-dehydrogenase

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IVD


High impact information on IVD


Anatomical context of IVD


Associations of IVD with chemical compounds

  • Such a dual activity has not been observed with the animal IVD and may suggest a novel connection of the Leu and valine catabolism in plants [1].
  • We have now identified a candidate protein and corresponding cDNA for an enzyme of the leucine catabolic pathway, the isovaleryl-CoA-dehydrogenase (IVD) [3].
  • We recently identified a cDNA encoding a putative isovaleryl-coenzyme A (CoA) dehydrogenase in Arabidopsis (AtIVD) [1].
  • Northern-blot hybridization and studies in transgenic Arabidopsis plants expressing Ativd promoter:gus constructs reveal strong expression of this gene in seedlings and young plants grown in the absence of sucrose, whereas promoter activity in almost all tissues is strongly inhibited by exogeneously added sucrose [1].

Analytical, diagnostic and therapeutic context of IVD

  • Two-dimensional separation of mitochondrial proteins by blue native and SDS-PAGE and size determination of the native and overexpressed proteins suggest homodimers to be the dominant form of the plant IVD [1].
  • Expression of the putative IVD gene in pea seedlings is documented by western blot analyses with an antibody against the mammalian IVD [3].


  1. The mitochondrial isovaleryl-coenzyme a dehydrogenase of arabidopsis oxidizes intermediates of leucine and valine catabolism. Däschner, K., Couée, I., Binder, S. Plant Physiol. (2001) [Pubmed]
  2. Cloning of a gene for an acyl-CoA dehydrogenase from Pisum sativum L. and purification and characterization of its product as an isovaleryl-CoA dehydrogenase. Reinard, T., Janke, V., Willard, J., Buck, F., Jacobsen, H.J., Vockley, J. J. Biol. Chem. (2000) [Pubmed]
  3. In plants a putative isovaleryl-CoA-dehydrogenase is located in mitochondria. Däschner, K., Thalheim, C., Guha, C., Brennicke, A., Binder, S. Plant Mol. Biol. (1999) [Pubmed]
WikiGenes - Universities