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Gene Review: 

ROC4  -  peptidyl-prolyl cis-trans isomerase CYP20-3

Arabidopsis thaliana

Synonyms: CYP20-3, PEPTIDYLPROLYL ISOMERASE ROC4, T17J13.1, cyclophilin 20-3, rotamase CYP 4
 
 
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High impact information on ROC4

  • In contrast, ROC4, which encodes a chloroplast stromal CyP, is interrupted by six introns [1].
  • Compared with the wild-type form, elimination of three out of the four cysteine residues decreased the catalytic efficiency of PPI (peptidyl-prolyl cis-trans isomerase) activity of the reduced CYP20-3, indicating a regulatory role of dithiol-disulfide transitions in protein function [2].
  • The rather negative E(m) (midpoint redox potential) of -319 mV places CYP20-3 into the redox hierarchy of the chloroplast, suggesting the activation of CYP20-3 in the light under conditions of limited acceptor availability for photosynthesis as realized under environmental stress [2].

References

  1. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Chou, I.T., Gasser, C.S. Plant Mol. Biol. (1997) [Pubmed]
  2. Role of the cysteine residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions. Laxa, M., K??nig, J., Dietz, K.J., Kandlbinder, A. Biochem. J. (2007) [Pubmed]
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