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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

J20  -  chaperone protein dnaJ 20

Arabidopsis thaliana

Synonyms: DNAJ-like 20, F18A5.220, F18A5_220
 
 
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Disease relevance of J20

  • The cDNA clones were expressed in Escherichia coli as fusion proteins, each of which oxidized GA12 at C-20 to GA15, GA24, and the C19 compound GA9, a precursor of bioactive GAs; the C20 tricarboxylic acid compound GA25 was formed as a minor product [1].
 

High impact information on J20

  • The ga5 mutant also had increased levels of certain C20-GAs, which indicates existence of an additional control, possibly hydroxylation of C-20 [2].
  • The ga5 mutant had reduced levels of the C19-GAs, which indicates that the product of the GA5 gene catalyzes the elimination of C-20 at the aldehyde level [2].
  • The method detects acyl CoA esters with acyl chain lengths from C4 to C20 down to concentrations as low as 6 fmol in extracts [3].
  • The open reading frame of the A. castellanii C20 Delta8-desaturase showed similarity to other microsomal front-end desaturases, but the N-terminal domain contained a variant form of the conserved heme-binding motif in which H-P-G-G is replaced by H-P-A-G [4].

References

  1. Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis. Phillips, A.L., Ward, D.A., Uknes, S., Appleford, N.E., Lange, T., Huttly, A.K., Gaskin, P., Graebe, J.E., Hedden, P. Plant Physiol. (1995) [Pubmed]
  2. Endogenous gibberellins in Arabidopsis thaliana and possible steps blocked in the biosynthetic pathways of the semidwarf ga4 and ga5 mutants. Talon, M., Koornneef, M., Zeevaart, J.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Technical Advance: a novel technique for the sensitive quantification of acyl CoA esters from plant tissues. Larson, T.R., Graham, I.A. Plant J. (2001) [Pubmed]
  4. The alternative pathway C20 Delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5-fusion desaturase. Sayanova, O., Haslam, R., Qi, B., Lazarus, C.M., Napier, J.A. FEBS Lett. (2006) [Pubmed]
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