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Gene Review

FAD6  -  omega-6 fatty acid desaturase

Arabidopsis thaliana

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High impact information on FAD6

  • However, a mutation in the plastidial membrane-localized omega6 desaturase (FAD6) mediates a partial rescue of ssi2-mediated phenotypes [1].
  • Although ssi2 fad6 plants are rescued in their morphological phenotypes, including larger size, absence of visible lesions, and straight leaves, these plants continue to exhibit microscopic cell death and express the PR-1 gene constitutively [1].
  • Mutants deficient in the chloroplast hexadecenoic acid/oleic acid desaturase (fad6) or hexadecadienoic acid/linoleic acid desaturase (fad7) had altered C6-aldehyde formation in a pattern similar to the changes in the PUFA [2].
  • The fad6 gene exhibited less sequence homology to any known higher plant desaturase, including an endoplasmic reticulum-localized omega 6 desaturase corresponding to the Arabidopsis fad2 gene [3].
  • When used as a hybridization probe, the cDNA identified a restriction fragment-length polymorphism that co-segregated with the fad6 mutation [3].

Biological context of FAD6

  • A putative fad6 cDNA clone was isolated by probing a cDNA library with a degenerate oligonucleotide based on a conserved region within known omega 3 desaturase genes [3].
  • The two maize fad6 cDNAs share 81% amino-acid identity with the Arabidopsis fad6 and map to chromosome 1 [4].

Anatomical context of FAD6


Associations of FAD6 with chemical compounds

  • None of the fad2 or fad6 clones mapped to maize chromosome bins associated with QTLs for the ratio of oleic/linoleic acid, notably bin 6.04 which contains the linoleic1 locus and the largest reported QTL for the oleic/linoleic ratio [4].

Analytical, diagnostic and therapeutic context of FAD6


  1. Plastidial fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant. Kachroo, A., Lapchyk, L., Fukushige, H., Hildebrand, D., Klessig, D., Kachroo, P. Plant Cell (2003) [Pubmed]
  2. The impact of alteration of polyunsaturated fatty acid levels on C6-aldehyde formation of Arabidopsis thaliana leaves. Zhuang, H., Hamilton-Kemp, T.R., Andersen, R.A., Hildebrand, D.F. Plant Physiol. (1996) [Pubmed]
  3. Identification of a gene that complements an Arabidopsis mutant deficient in chloroplast omega 6 desaturase activity. Falcone, D.L., Gibson, S., Lemieux, B., Somerville, C. Plant Physiol. (1994) [Pubmed]
  4. Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. Mikkilineni, V., Rocheford, T.R. Theor. Appl. Genet. (2003) [Pubmed]
  5. Cloning of a higher-plant plastid omega-6 fatty acid desaturase cDNA and its expression in a cyanobacterium. Hitz, W.D., Carlson, T.J., Booth, J.R., Kinney, A.J., Stecca, K.L., Yadav, N.S. Plant Physiol. (1994) [Pubmed]
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