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Gene Review:

WRKY18 - WRKY DNA-binding protein 18

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA WRKY DNA-BINDING PROTEIN 18, ATWRKY18, F11C18.16

Chen, C. et al., Xu, X. et al.

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Disease relevance of WRKY18

As they grew from seedling to mature stages, transgenic AtWRKY18 plant showed marked increase in the expression of pathogenesis-related genes and resistance to the bacterial pathogen Pseudomonas syringae, whereas wild-type plants exhibited little enhancement in these defense responses [1].
In the present study, we have transformed Arabidopsis plants with AtWRKY18 under control of the cauliflower mosaic virus 35S promoter [1].

High impact information on WRKY18

2. While constitutive expression of WRKY18 enhanced resistance to P. syringae, its coexpression with WRKY40 or WRKY60 made plants more susceptible to both P. syringae and B. cinerea [2].
We report physical and functional interactions between structurally related and pathogen-induced WRKY18, WRKY40, and WRKY60 transcription factors in Arabidopsis thaliana [2].
AtWRKY18 is a pathogen- and salicylic acid-induced Arabidopsis transcription factor containing the plant-specific WRKY zinc finger DNA-binding motif [1].
Thus, AtWRKY18 can positively modulate defense-related gene expression and disease resistance [1].
Potentiation of developmentally regulated defense responses by AtWRKY18 was not associated with enhanced biosynthesis of salicylic acid but required the disease resistance regulatory protein NPR1/NIM1 [1].

Biological context of WRKY18

These negative cis-acting elements may prevent overexpression of AtWRKY18 during the activation of plant defense responses that could be detrimental to plant growth as inferred from the transgenic plants ectopically expressing the transgene [1].

References

Potentiation of developmentally regulated plant defense response by AtWRKY18, a pathogen-induced Arabidopsis transcription factor. Chen, C., Chen, Z. Plant Physiol. (2002) [Pubmed]
Physical and Functional Interactions between Pathogen-Induced Arabidopsis WRKY18, WRKY40, and WRKY60 Transcription Factors. Xu, X., Chen, C., Fan, B., Chen, Z. Plant Cell (2006) [Pubmed]

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