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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HEMC  -  Porphobilinogen deaminase

Arabidopsis thaliana

Synonyms: F8L15.10, F8L15_10, PORPHOBILINOGEN DEAMINASE, RUG1, RUGOSA 1, ...
 
 
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Disease relevance of HEMC

 

High impact information on HEMC

  • Using degenerate oligonucleotide primers, based on amino acid sequence data for purified PBG deaminase from pea, a fragment was amplified from Arabidopsis genomic DNA by PCR, and then used to isolate both a cDNA and a genomic clone for PBG deaminase from Arabidopsis [2].
  • These results support the conclusion that there is only one form of PBG deaminase in all plant cells, which is located in the plastid [2].
  • Southern blot analysis suggests that PBG deaminase is encoded by a single gene in the Arabidopsis genome, and RNase protection experiments demonstrated that this gene is expressed in both leaves and roots [2].

References

  1. Subcellular location of the tetrapyrrole synthesis enzyme porphobilinogen deaminase in higher plants: an immunological investigation. Witty, M., Jones, R.M., Robb, M.S., Jordan, P.M., Smith, A.G. Planta (1996) [Pubmed]
  2. Porphobilinogen deaminase is encoded by a single gene in Arabidopsis thaliana and is targeted to the chloroplasts. Lim, S.H., Witty, M., Wallace-Cook, A.D., Ilag, L.I., Smith, A.G. Plant Mol. Biol. (1994) [Pubmed]
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