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Gene Review:

CYP20-2 - peptidyl-prolyl cis-trans isomerase CYP20-2

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA CYCLOPHILIN 20-2, ATCYP20-2, Photosynthetic NDH subcomplex L 5, Pnsl5, T19L5.80, ...

Laxa, M. et al., Edvardsson, A. et al., Romano, P.G. et al.

Romano, Edvardsson, Ruban, Andersson, Vener, Gray, Horton,

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High impact information on AT5G13120

Arabidopsis AtCYP20-2 is a light-regulated cyclophilin-type peptidyl-prolyl cis-trans isomerase associated with the photosynthetic membranes [1].
TLP20 was inhibited by cyclosporin A and mass spectrometric sequencing of tryptic peptides confirmed its classification as a cyclophilin [2].
TLP20 is suggested to be the major PPIase and protein folding catalyst in the thylakoid lumen of plant chloroplasts [2].
Compared with the wild-type form, elimination of three out of the four cysteine residues decreased the catalytic efficiency of PPI (peptidyl-prolyl cis-trans isomerase) activity of the reduced CYP20-3, indicating a regulatory role of dithiol-disulfide transitions in protein function [3].
Role of the cysteine residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions [3].

References

Arabidopsis AtCYP20-2 is a light-regulated cyclophilin-type peptidyl-prolyl cis-trans isomerase associated with the photosynthetic membranes. Romano, P.G., Edvardsson, A., Ruban, A.V., Andersson, B., Vener, A.V., Gray, J.E., Horton, P. Plant Physiol. (2004) [Pubmed]
The major peptidyl-prolyl isomerase activity in thylakoid lumen of plant chloroplasts belongs to a novel cyclophilin TLP20. Edvardsson, A., Eshaghi, S., Vener, A.V., Andersson, B. FEBS Lett. (2003) [Pubmed]
Role of the cysteine residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions. Laxa, M., K??nig, J., Dietz, K.J., Kandlbinder, A. Biochem. J. (2007) [Pubmed]

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