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Gene Review

COL1  -  zinc finger protein CONSTANS-LIKE 1

Arabidopsis thaliana

Synonyms: ATCOL1, B-box domain protein 2, BBX2, CONSTANS-like 1, F14F8.230, ...
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High impact information on COL1

  • The CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain is found in 45 Arabidopsis thaliana proteins involved in processes such as photoperiodic flowering, light signaling, and regulation of circadian rhythms [1].
  • Systemic pathogen-induced expression of the plant defensin gene was unaffected in Arabidopsis transformants (nahG) or mutants (npr1 and cpr1) affected in the salicylic acid response but was strongly reduced in the Arabidopsis mutants eln2 and col1 that are blocked in their response to ethylene and methyl jasmonate, respectively [2].
  • Summary CONSTANS-Like (COL) proteins are plant-specific nuclear regulators of gene expression but do not contain a known DNA-binding motif [3].
  • Overexpression of COL9, a CONSTANS-LIKE gene, delays flowering by reducing expression of CO and FT in Arabidopsis thaliana [4].
  • They were highly similar to each other and to Hd1, and in addition harbored two conserved regions: two zinc finger motifs and CONSTANS, CONSTANS-LIKE and TIMING OF CAB EXPRESSION 1 (CCT) domain like CO/Hd1 [5].

Biological context of COL1


Physical interactions of COL1

  • The LKP2-binding site in CO or COL1 was near the center of each protein [10].

Other interactions of COL1


  1. CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis. Wenkel, S., Turck, F., Singer, K., Gissot, L., Le Gourrierec, J., Samach, A., Coupland, G. Plant Cell (2006) [Pubmed]
  2. Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway. Penninckx, I.A., Eggermont, K., Terras, F.R., Thomma, B.P., De Samblanx, G.W., Buchala, A., Métraux, J.P., Manners, J.M., Broekaert, W.F. Plant Cell (1996) [Pubmed]
  3. The CCAAT binding factor can mediate interactions between CONSTANS-like proteins and DNA. Ben-Naim, O., Eshed, R., Parnis, A., Teper-Bamnolker, P., Shalit, A., Coupland, G., Samach, A., Lifschitz, E. Plant J. (2006) [Pubmed]
  4. Overexpression of COL9, a CONSTANS-LIKE gene, delays flowering by reducing expression of CO and FT in Arabidopsis thaliana. Cheng, X.F., Wang, Z.Y. Plant J. (2005) [Pubmed]
  5. Characterization and functional analysis of three wheat genes with homology to the CONSTANS flowering time gene in transgenic rice. Nemoto, Y., Kisaka, M., Fuse, T., Yano, M., Ogihara, Y. Plant J. (2003) [Pubmed]
  6. Analysis of the function of two circadian-regulated CONSTANS-LIKE genes. Ledger, S., Strayer, C., Ashton, F., Kay, S.A., Putterill, J. Plant J. (2001) [Pubmed]
  7. Naturally occurring indel variation in the Brassica nigra COL1 gene is associated with variation in flowering time. Osterberg, M.K., Shavorskaya, O., Lascoux, M., Lagercrantz, U. Genetics (2002) [Pubmed]
  8. Molecular cloning and expression analysis of a CONSTANS homologue, PnCOL1, from Pharbitis nil. Kim, S.J., Moon, J., Lee, I., Maeng, J., Kim, S.R. J. Exp. Bot. (2003) [Pubmed]
  9. Expressed sequence tags of radish flower buds and characterization of a CONSTANS LIKE 1 gene. Moon, Y.H., Chae, S., Jung, J.Y., An, G. Mol. Cells (1998) [Pubmed]
  10. Identification of LOV KELCH PROTEIN2 (LKP2)-interacting factors that can recruit LKP2 to nuclear bodies. Fukamatsu, Y., Mitsui, S., Yasuhara, M., Tokioka, Y., Ihara, N., Fujita, S., Kiyosue, T. Plant Cell Physiol. (2005) [Pubmed]
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