Disease relevance of KIN1

• In addition to being expressed in cold, kin1 is also induced by water stress and the plant hormone abscisic acid (ABA) which has been suggested to be a common mediator for osmotic stress responses and cold acclimation in plants [1].

High impact information on KIN1

• Similarly, sfr 6 plants failed to induce KIN1 normally in response to either osmotic stress or the application of abscisic acid [2].
• We tested plants homozygous for mutations sfr2 to sfr7 for cold-induced gene expression and found that sfr 6 plants were deficient in cold-inducible expression of the genes KIN1, COR15a, and LTI78, which all contain the C repeat/dehydration-responsive element (CRT/DRE) motif in their promoters [2].
• In Arabidopsis, lanthanum or EGTA caused a partial inhibition of both cold shock [Ca2+]cyt elevation and cold-dependent kin1 gene expression [3].
• Expression of the stress-inducible COR15A and KIN1 gene in hot2 mutants in response to increased NaCl concentrations was normal [4].
• Together these results reveal induction of kin1 and cor6.6 transcription by low temperature, exogenous ABA and dehydration [5].

Chemical compound and disease context of KIN1

• Promoters from kin1 and cor6.6, two homologous Arabidopsis thaliana genes: transcriptional regulation and gene expression induced by low temperature, ABA, osmoticum and dehydration [5].

Biological context of KIN1

• COR6.6 is almost identical to KIN1, a cold-regulated Arabidopsis gene that has been suggested to have amino acid sequence similarities with type I fish antifreeze proteins (S. Kurkela, M. Franck, Plant Mol Biol 15: 137-144, 1990) [6].
• We have identified by differential screening a novel Arabidopsis thaliana gene, called kin1, which is induced at +4 degrees C. The nucleotide sequences of both the genomic clone and the corresponding cDNA were determined [1].
• Kin1 and kin2 are organized in a close tandem array in the genome of A. thaliana [7].
• These patterns of expression distinguish kin1 and cor6.6 from related lea genes which are strongly expressed during late embryogenesis [8].

Associations of KIN1 with chemical compounds

• The Arabidopsis thaliana genes kin1 and cor6.6 belong to the same family and were expressed at higher levels following low temperature and ABA treatments [5].

Analytical, diagnostic and therapeutic context of KIN1

• Northern blot analysis revealed that the level of kin1 mRNA is increased 20-fold in cold-treated plants [1].

References