High impact information on KLK

• NAPP and PIRP encode subunits of a putative wave regulatory protein complex involved in plant cell morphogenesis [1].
• PIROGI directly interacts with the small GTPase ATROP2 with isoform specificity and with selectivity for active forms of the protein [2].
• The patterns and levels of actin polymerization observed in Atnap-1 and Atpir-1 mutant trichome cells and epidermal pavement cell morphology is consistent with Arabidopsis NAP and PIR proteins forming a WAVE complex that activates ARP2/3 activity [3].
• Arabidopsis NAP and PIR regulate actin-based cell morphogenesis and multiple developmental processes [3].
• The Arabidopsis KLUNKER gene controls cell shape changes and encodes the AtSRA1 homolog [4].

Biological context of KLK

• Recently, a single, centralized, authoritative resource for protein sequences and functional information, UniProt, was created by joining the information contained in Swiss-Prot, Translation of the EMBL nucleotide sequence (TrEMBL), and the Protein Information Resource-Protein Sequence Database (PIR-PSD) [5].

Other interactions of KLK

• In animal cells ARP2/3 activity is regulated by WAVE complexes that contain WAVE/SCAR proteins, PIR121, Nap125, and other proteins [3].

References