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Gene Review

RBX1  -  RING-box protein 1

Arabidopsis thaliana

Synonyms: ATRBX1, F7C8.160, F7C8_160, HRT1, REGULATOR OF CULLINS-1, ...
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High impact information on RBX1

  • In addition, we show that RCE1 interacts directly with the RING protein RBX1 and is present in a stable complex with SCF [1].
  • We propose that RBX1 functions as an E3 for RUB modification of CUL1 [1].
  • Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development [2].
  • A large collection of E3s use Cullins (CULs) as scaffolds to form multisubunit E3 complexes in which the CUL binds a target recognition subcomplex and the RBX1 docking protein, which delivers the activated ubiquitin moiety [3].
  • Reduced levels of the core SCF component AtRBX1 phenocopy the long period phenotype of ztl loss-of-function mutations, demonstrating the functional significance of the SCFZTL complex [4].


  1. The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. Dharmasiri, S., Dharmasiri, N., Hellmann, H., Estelle, M. EMBO J. (2003) [Pubmed]
  2. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Chen, H., Shen, Y., Tang, X., Yu, L., Wang, J., Guo, L., Zhang, Y., Zhang, H., Feng, S., Strickland, E., Zheng, N., Deng, X.W. Plant Cell (2006) [Pubmed]
  3. Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. Gingerich, D.J., Gagne, J.M., Salter, D.W., Hellmann, H., Estelle, M., Ma, L., Vierstra, R.D. J. Biol. Chem. (2005) [Pubmed]
  4. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Han, L., Mason, M., Risseeuw, E.P., Crosby, W.L., Somers, D.E. Plant J. (2004) [Pubmed]
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