The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

UVH1  -  DNA repair endonuclease UVH1

Arabidopsis thaliana

Synonyms: ATRAD1, MEE6.22, MEE6_22, RAD1, REPAIR ENDONUCLEASE, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of UVH1

 

High impact information on UVH1

  • Decreased repair of methylene blue-induced oxidative lesions, which are believed to be processed by the base excision repair machinery in mammalian cells, may indicate a possible involvement of AtRAD1 in the repair of oxidative damage [3].
  • A new assay for DNA damage, the Dral assay, was developed and used to show that exposure of wild-type and uvh1 plants to a given dose of UV light induces the same amount of damage in chloroplast and nuclear DNA [1].
  • The UVH1 locus was mapped to chromosome 5 and the position of the UVH1 gene was further delineated by Agrobacterium-mediated transformation of the uvh1-1 mutant with cosmids from this location [4].
  • Here we find that gamma irradiation of uvh1 plants specifically triggers a G(2)-phase cell cycle arrest [5].
  • Transient expression of a T-DNA encoded ss-glucuronidase (GUS) gene and stable kanamycin resistance were obtained for the ten ARABIDOPSIS: genotypes tested as well as for the mutant uvh1 (up to 69% of petioles with blue spots and up to 42% resistant calli) [6].
 

Biological context of UVH1

References

  1. Isolation of uvh1, an Arabidopsis mutant hypersensitive to ultraviolet light and ionizing radiation. Harlow, G.R., Jenkins, M.E., Pittalwala, T.S., Mount, D.W. Plant Cell (1994) [Pubmed]
  2. Agrobacterium tumefaciens transformation of the radiation hypersensitive Arabidopsis thaliana mutants uvh1 and rad5. Nam, J., Mysore, K.S., Gelvin, S.B. Mol. Plant Microbe Interact. (1998) [Pubmed]
  3. Repair of damaged DNA by Arabidopsis cell extract. Li, A., Schuermann, D., Gallego, F., Kovalchuk, I., Tinland, B. Plant Cell (2002) [Pubmed]
  4. Repair of UV damage in plants by nucleotide excision repair: Arabidopsis UVH1 DNA repair gene is a homolog of Saccharomyces cerevisiae Rad1. Liu, Z., Hossain, G.S., Islas-Osuna, M.A., Mitchell, D.L., Mount, D.W. Plant J. (2000) [Pubmed]
  5. A DNA-damage-induced cell cycle checkpoint in Arabidopsis. Preuss, S.B., Britt, A.B. Genetics (2003) [Pubmed]
  6. Competence of Arabidopsis thaliana genotypes and mutants for Agrobacterium tumefaciens-mediated gene transfer: role of phytohormones. Chateau, S., Sangwan, R.S., Sangwan-Norreel, B.S. J. Exp. Bot. (2000) [Pubmed]
 
WikiGenes - Universities