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Gene Review

CUC2  -  protein CUP-SHAPED COTYLEDON 2

Arabidopsis thaliana

Synonyms: ANAC098, ATCUC2, Arabidopsis NAC domain containing protein 98, CUP-SHAPED COTYLEDON 2, K19P17.12, ...
 
 
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High impact information on CUC2

  • Enhanced leaf serration was observed following the expression of an miR164-resistant CUC2 but not of an miR164-resistant CUC1 [1].
  • CUC1 and CUC2 transcripts are targeted by a microRNA (miRNA), miR164, encoded by MIR164A, B, and C. We show that each MIR164 is transcribed to generate a large population of primary miRNAs of variable size with a locally conserved secondary structure around the pre-miRNA [1].
  • In agreement with this fact, CUC1 and CUC2 were redundantly required for KNAT6 expression [2].
  • In embryogenesis, all three genes make significant contributions, although CUC3 appears to possess, at least partially, a distinct function from that of CUC1 and CUC2 [3].
  • We cloned the CUC2 gene and found that the encoded protein was homologous to the petunia NO APICAL MERISTEM (NAM) protein, which is thought to act in the development of embryos and flowers [4].
 

Biological context of CUC2

  • By investigating the activities of the CUC promoters in the cotyledon boundary during embryogenesis in sensitized backgrounds, we demonstrate that AtBRM upregulates the transcription of all three CUC genes, whereas SYD upregulates the expression of CUC2 [5].
  • In order to identify novel regulators of this process, we have performed a phenotypical enhancer screen using a null allele of cuc2, cuc2-1 [5].
  • Our results reveal that redundant but partially distinct functions of CUC1, CUC2, and CUC3 are responsible for shoot organ boundary and meristem formation throughout the life cycle in Arabidopsis [3].
 

Associations of CUC2 with chemical compounds

 

Other interactions of CUC2

  • The CUP-SHAPED COTYLEDON (CUC) genes CUC1, CUC2 and CUC3 act redundantly to control cotyledon separation in Arabidopsis [5].
  • The balance between coexpressed CUC2 and MIR164A then determines the extent of serration [1].
  • Finally, BrdU incorporation and CUC2 in situ hybridisation patterns were analysed in two mutant backgrounds, agamous (ag)-1 and superman (sup)-1, in order to assess changes in boundary establishment and different levels of indeterminacy under conditions of altered proliferation at the floral meristem centre [7].

References

  1. The Balance between the MIR164A and CUC2 Genes Controls Leaf Margin Serration in Arabidopsis. Nikovics, K., Blein, T., Peaucelle, A., Ishida, T., Morin, H., Aida, M., Laufs, P. Plant Cell (2006) [Pubmed]
  2. KNAT6: an Arabidopsis homeobox gene involved in meristem activity and organ separation. Belles-Boix, E., Hamant, O., Witiak, S.M., Morin, H., Traas, J., Pautot, V. Plant Cell (2006) [Pubmed]
  3. Arabidopsis CUP-SHAPED COTYLEDON3 Regulates Postembryonic Shoot Meristem and Organ Boundary Formation. Hibara, K., Karim, M.R., Takada, S., Taoka, K., Furutani, M., Aida, M., Tasaka, M. Plant Cell (2006) [Pubmed]
  4. Genes involved in organ separation in Arabidopsis: an analysis of the cup-shaped cotyledon mutant. Aida, M., Ishida, T., Fukaki, H., Fujisawa, H., Tasaka, M. Plant Cell (1997) [Pubmed]
  5. A role for chromatin remodeling in regulation of CUC gene expression in the Arabidopsis cotyledon boundary. Kwon, C.S., Hibara, K., Pfluger, J., Bezhani, S., Metha, H., Aida, M., Tasaka, M., Wagner, D. Development (2006) [Pubmed]
  6. The CUP-SHAPED COTYLEDON1 gene of Arabidopsis regulates shoot apical meristem formation. Takada, S., Hibara, K., Ishida, T., Tasaka, M. Development (2001) [Pubmed]
  7. High-resolution boundary analysis during Arabidopsis thaliana flower development. Breuil-Broyer, S., Morel, P., de Almeida-Engler, J., Coustham, V., Negrutiu, I., Trehin, C. Plant J. (2004) [Pubmed]
 
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