Disease relevance of THI1

• The plant homolog thi1, from Arabidopsis thaliana, is also involved in thiamine biosynthesis; but was originally cloned due to its capacity to complement DNA repair deficient phenotypes in Escherichia coli [1].

High impact information on THI1

• Structure of the Thiazole Biosynthetic Enzyme THI1 from Arabidopsis thaliana [2].
• Partially overlapping localization of Ara6 and Ara7/Rha1 with reciprocal gradients suggests maturation of endosomes from one to the other [3].
• In contrast, the plant-unique Rab5, Ara6, resides on distinct endosomes with the prevacuolar SNAREs [3].
• Thus, Thi4 and its plant homolog appear to be dual functional proteins with roles in thiamine biosynthesis and mitochondrial DNA damage tolerance [1].
• Here, the behavior of a thi4 disrupted strain was examined for increased sensitivity to treatment with the DNA damaging agents ultraviolet radiation (UV, 254 nm) and methyl methanesulfonate (MMS) [1].

Biological context of THI1

• Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repair [4].

Anatomical context of THI1

• Dual targeting properties of the N-terminal signal sequence of Arabidopsis thaliana THI1 protein to mitochondria and chloroplasts [5].

Associations of THI1 with chemical compounds

• THI1 has a topology similar to dinucleotide binding domains and although details concerning its function are unknown, this work provides new clues about the thiazole biosynthesis in Eukaryotes [2].

References