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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pafah1b1  -  platelet-activating factor acetylhydrolase...

Rattus norvegicus

Synonyms: LIS-1, Lis-1, Lis1, Lissencephaly-1 protein, PAF acetylhydrolase 45 kDa subunit, ...
 
 
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High impact information on Pafah1b1

  • Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1 [1].
  • Lis1 deficiency produces the opposite phenotype [1].
  • Expression of LIS1 in the dentate gyrus changed significantly in a manner similar to that of PAF-AH enzymatic activity [2].
  • Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures [2].
  • In order to gain molecular insights into the possible involvement of LIS1 in seizures in lissencephaly patients, we induced seizures in rats by injection of kainate [2].
 

Other interactions of Pafah1b1

References

  1. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Smith, D.S., Niethammer, M., Ayala, R., Zhou, Y., Gambello, M.J., Wynshaw-Boris, A., Tsai, L.H. Nat. Cell Biol. (2000) [Pubmed]
  2. Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. Shmueli, O., Cahana, A., Reiner, O. J. Neurosci. Res. (1999) [Pubmed]
  3. A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. Kizhatil, K., Wu, Y.X., Sen, A., Bennett, V. J. Neurosci. (2002) [Pubmed]
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