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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PEX5  -  peroxisome biogenesis protein 5

Arabidopsis thaliana

Synonyms: ARABIDOPSIS PEROXIN 5, ATPEX5, EMB2790, EMBRYO DEFECTIVE 2790, MXK23.3, ...
 
 
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High impact information on PEX5

  • Expression of the PEX5 and PEX7 genes was efficiently reduced by the double-stranded RNA-mediated interference in the transgenic Arabidopsis [1].
  • An identical phenotype was observed in a transgenic Arabidopsis overexpressing functionally defective Pex5p [1].
  • The Arabidopsis T-DNA insertional pex5 mutant, Atpex5, which does not germinate in the absence of sucrose and was resistant to indole-3-butyric acid (IBA), was perfectly rescued by over-expression of OsPex5pL, but not by OsPex5pS [2].
 

Biological context of PEX5

  • To demonstrate the contribution of Pex5p and Pex7p to the maintenance of peroxisomal functions in plants, double-stranded RNA constructs were introduced into the genome of Arabidopsis thaliana [1].
 

Anatomical context of PEX5

  • Most peroxisomal matrix proteins bear characterized Peroxisomal Targeting Signals (PTS1 or PTS2), which are bound by the receptors PEX5 or PEX7, respectively, for import into peroxisomes [3].

References

  1. Differential contribution of two peroxisomal protein receptors to the maintenance of peroxisomal functions in Arabidopsis. Hayashi, M., Yagi, M., Nito, K., Kamada, T., Nishimura, M. J. Biol. Chem. (2005) [Pubmed]
  2. Cloning of two splice variants of the rice PTS1 receptor, OsPex5pL and OsPex5pS, and their functional characterization using pex5-deficient yeast and Arabidopsis. Lee, J.R., Jang, H.H., Park, J.H., Jung, J.H., Lee, S.S., Park, S.K., Chi, Y.H., Moon, J.C., Lee, Y.M., Kim, S.Y., Kim, J.Y., Yun, D.J., Cho, M.J., Lee, K.O., Lee, S.Y. Plant J. (2006) [Pubmed]
  3. The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5. Woodward, A.W., Bartel, B. Mol. Biol. Cell (2005) [Pubmed]
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