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Gene Review

SIZ1  -  E3 SUMO-protein ligase SIZ1

Arabidopsis thaliana

Synonyms: AT5G60420, ATSIZ1, MUF9.5, MUF9_5
 
 
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Disease relevance of SIZ1

  • Mutant siz1 plants exhibit constitutive systemic-acquired resistance (SAR) characterized by elevated accumulation of salicylic acid (SA), increased expression of pathogenesis-related (PR) genes, and increased resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) DC3000 [1].
 

High impact information on SIZ1

  • In contrast, siz1 plants were not resistant to Pst DC3000 expressing avrRpm1, a bacterial avirulence determinant that responds to the NDR1-dependent CC-NBS-type R gene [1].
  • Here, we show that the SIZ1 gene, which encodes an Arabidopsis SUMO E3 ligase, regulates innate immunity [1].
  • Transfer of the NahG gene to siz1 plants results in reversal of these phenotypes back to wild-type [1].
  • Jasmonic acid (JA)-induced PDF1.2 expression and susceptibility to Botrytis cinerea were unaltered in siz1 plants [1].
  • Notable examples include novel alleles of SOS1 and mutations to genes encoding the STT3a subunit of the oligosaccharyltransferase, syntaxin, RNA polymerase II CTD phosphatases, transcription factors, ABA biosynthetic enzyme, Na(+) transporter HKT1, and SUMO E3 ligase [2].
 

Regulatory relationships of SIZ1

References

  1. Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Lee, J., Nam, J., Park, H.C., Na, G., Miura, K., Jin, J.B., Yoo, C.Y., Baek, D., Kim, D.H., Jeong, J.C., Kim, D., Lee, S.Y., Salt, D.E., Mengiste, T., Gong, Q., Ma, S., Bohnert, H.J., Kwak, S.S., Bressan, R.A., Hasegawa, P.M., Yun, D.J. Plant J. (2007) [Pubmed]
  2. Identification of plant stress-responsive determinants in arabidopsis by large-scale forward genetic screens. Koiwa, H., Bressan, R.A., Hasegawa, P.M. J. Exp. Bot. (2006) [Pubmed]
  3. The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure. Jin, J.B., Jin, Y.H., Lee, J., Miura, K., Yoo, C.Y., Kim, W.Y., Van Oosten, M., Hyun, Y., Somers, D.E., Lee, I., Yun, D.J., Bressan, R.A., Hasegawa, P.M. Plant J. (2008) [Pubmed]
 
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