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Gene Review

FKBP12  -  peptidyl-prolyl isomerase FKBP12

Arabidopsis thaliana

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High impact information on FKBP12

  • However, Arabidopsis seedlings do not respond to normal physiological levels of rapamycin, which appears to be due its inability to bind to the Arabidopsis homolog of FKBP12, a protein that is essential for the binding of rapamycin with TOR [1].
  • Here, we report that an immunophilin of the chloroplast thylakoid lumen is required for accumulation of the PSII supercomplex in Arabidopsis thaliana [2].
  • The immunophilin, FKBP20-2, belongs to the FK-506 binding protein (FKBP) subfamily that functions as peptidyl-prolyl isomerases (PPIases) in protein folding [2].
  • Immunophilin-like TWISTED DWARF1 Modulates Auxin Efflux Activities of Arabidopsis P-glycoproteins [3].
  • FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants [4].

Biological context of FKBP12


Physical interactions of FKBP12

  • Furthermore, pull-down assays demonstrated that TOR binds FKBP12 in the presence of rapamycin [6].
  • FKBP12 is a binding protein for the type I receptors of the TGF-beta family ligands [7].

Other interactions of FKBP12

  • AtFIP37 is similar to a mammalian protein, FAP48, that also binds to FKBP12 [8].



  1. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals. Mahfouz, M.M., Kim, S., Delauney, A.J., Verma, D.P. Plant Cell (2006) [Pubmed]
  2. A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana. Lima, A., Lima, S., Wong, J.H., Phillips, R.S., Buchanan, B.B., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Immunophilin-like TWISTED DWARF1 Modulates Auxin Efflux Activities of Arabidopsis P-glycoproteins. Bouchard, R., Bailly, A., Blakeslee, J.J., Oehring, S.C., Vincenzetti, V., Lee, O.R., Paponov, I., Palme, K., Mancuso, S., Murphy, A.S., Schulz, B., Geisler, M. J. Biol. Chem. (2006) [Pubmed]
  4. Crystal Structure of a Multi-domain Immunophilin from Arabidopsis thaliana: A Paradigm for Regulation of Plant ABC Transporters. Granzin, J., Eckhoff, A., Weiergr??ber, O.H. J. Mol. Biol. (2006) [Pubmed]
  5. The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Vespa, L., Vachon, G., Berger, F., Perazza, D., Faure, J.D., Herzog, M. Plant Physiol. (2004) [Pubmed]
  6. Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii. Crespo, J.L., Díaz-Troya, S., Florencio, F.J. Plant Physiol. (2005) [Pubmed]
  7. The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors. Wang, T., Donahoe, P.K. Front. Biosci. (2004) [Pubmed]
  8. An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. Faure, J.D., Gingerich, D., Howell, S.H. Plant J. (1998) [Pubmed]
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