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Gene Review

Trpv1  -  transient receptor potential cation...

Rattus norvegicus

Synonyms: Capsaicin receptor, OTRPC1, Osm-9-like TRP channel 1, TRPV1_SON, Transient receptor potential cation channel subfamily V member 1, ...
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Disease relevance of Trpv1


Psychiatry related information on Trpv1


High impact information on Trpv1


Chemical compound and disease context of Trpv1


Biological context of Trpv1


Anatomical context of Trpv1


Associations of Trpv1 with chemical compounds

  • Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to encode an ion channel that is activated by both capsaicin, the pain producing compound in chili peppers, and by noxious thermal stimuli [1].
  • CONCLUSION: These results suggest, for the first time, that the hypotensive effect of Rut is mediated by stimulation of CGRP synthesis and release via activation of VR1 in the phenol-induced hypertensive rat [17].
  • The effects of anandamide and 2-AG were significantly inhibited by pretreatment with the specific capsaicin receptor (vanilloid receptor subtype 1; VR1) antagonist capsazepine [3].
  • Capsaicin perfusion into the left renal pelvis but not intravenously caused significant increases in urine flow rate and urinary sodium excretion bilaterally in a dose-dependent manner, which were abolished by capsazepine, a selective VR1 receptor antagonist, given ipsilaterally to the renal pelvis or by ipsilateral renal denervation [16].
  • Most of VR1 immunoreactive nerves were also immunoreactive for SP or CGRP [20].

Regulatory relationships of Trpv1


Other interactions of Trpv1


Analytical, diagnostic and therapeutic context of Trpv1


  1. Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. Schumacher, M.A., Moff, I., Sudanagunta, S.P., Levine, J.D. J. Biol. Chem. (2000) [Pubmed]
  2. Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons. Guo, A., Simone, D.A., Stone, L.S., Fairbanks, C.A., Wang, J., Elde, R. Eur. J. Neurosci. (2001) [Pubmed]
  3. Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). McVey, D.C., Schmid, P.C., Schmid, H.H., Vigna, S.R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  4. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. Hong, S., Wiley, J.W. J. Biol. Chem. (2005) [Pubmed]
  5. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. Harada, N., Okajima, K., Isobe, H., Uchiba, M. Thromb. Haemost. (2006) [Pubmed]
  6. Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats. Horie, S., Yamamoto, H., Michael, G.J., Uchida, M., Belai, A., Watanabe, K., Priestley, J.V., Murayama, T. Scand. J. Gastroenterol. (2004) [Pubmed]
  7. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Chuang , H.H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., Julius, D. Nature (2001) [Pubmed]
  8. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Zygmunt, P.M., Petersson, J., Andersson, D.A., Chuang, H., Sørgård, M., Di Marzo, V., Julius, D., Högestätt, E.D. Nature (1999) [Pubmed]
  9. A capsaicin-receptor homologue with a high threshold for noxious heat. Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J., Julius, D. Nature (1999) [Pubmed]
  10. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. Tognetto, M., Amadesi, S., Harrison, S., Creminon, C., Trevisani, M., Carreras, M., Matera, M., Geppetti, P., Bianchi, A. J. Neurosci. (2001) [Pubmed]
  11. Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice. Pethö, G., Izydorczyk, I., Reeh, P.W. Pain (2004) [Pubmed]
  12. Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells. Tang, H.B., Inoue, A., Oshita, K., Hirate, K., Nakata, Y. Neuropharmacology (2005) [Pubmed]
  13. Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Bernardini, N., Neuhuber, W., Reeh, P.W., Sauer, S.K. Neuroscience (2004) [Pubmed]
  14. Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. Li, J., Kaminski, N.E., Wang, D.H. Hypertension (2003) [Pubmed]
  15. VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. Stenholm, E., Bongenhielm, U., Ahlquist, M., Fried, K. Acta Odontol. Scand. (2002) [Pubmed]
  16. Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats. Zhu, Y., Wang, Y., Wang, D.H. Hypertension (2005) [Pubmed]
  17. Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine. Deng, P.Y., Ye, F., Cai, W.J., Tan, G.S., Hu, C.P., Deng, H.W., Li, Y.J. J. Hypertens. (2004) [Pubmed]
  18. Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Fernihough, J., Gentry, C., Bevan, S., Winter, J. Neurosci. Lett. (2005) [Pubmed]
  19. Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae. Ishida, Y., Ugawa, S., Ueda, T., Murakami, S., Shimada, S. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  20. Immunolocalization of VR1 and VRL1 in rat larynx. Yamamoto, Y., Taniguchi, K. Autonomic neuroscience : basic & clinical. (2005) [Pubmed]
  21. The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons. Ahluwalia, J., Rang, H., Nagy, I. Eur. J. Neurosci. (2002) [Pubmed]
  22. Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. Minowa, S., Ishihara, S., Tsuchiya, S., Horie, S., Murayama, T. Brain Res. (2005) [Pubmed]
  23. Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. Kawao, N., Shimada, C., Itoh, H., Kuroda, R., Kawabata, A. Jpn. J. Pharmacol. (2002) [Pubmed]
  24. Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. Hudson, L.J., Bevan, S., McNair, K., Gentry, C., Fox, A., Kuhn, R., Winter, J. J. Neurosci. (2002) [Pubmed]
  25. The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia. Ichikawa, H., Sugimoto, T. Brain Res. (2003) [Pubmed]
  26. The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells. Doly, S., Fischer, J., Conrath, M. Brain Res. (2004) [Pubmed]
  27. Existence of brain-derived neurotrophic factor and vanilloid receptor subtype 1 immunoreactive sensory DRG neurons innervating L5/6 intervertebral discs in rats. Ohtori, S., Takahashi, K., Moriya, H. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2003) [Pubmed]
  28. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Akiba, Y., Ghayouri, S., Takeuchi, T., Mizumori, M., Guth, P.H., Engel, E., Swenson, E.R., Kaunitz, J.D. Gastroenterology (2006) [Pubmed]
  29. Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract. Patterson, L.M., Zheng, H., Ward, S.M., Berthoud, H.R. Cell Tissue Res. (2003) [Pubmed]
  30. Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death. Amantini, C., Mosca, M., Lucciarini, R., Perfumi, M., Morrone, S., Piccoli, M., Santoni, G. Cell Death Differ. (2004) [Pubmed]
  31. VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation. Fukuoka, T., Tokunaga, A., Tachibana, T., Dai, Y., Yamanaka, H., Noguchi, K. Pain (2002) [Pubmed]
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