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Gene Review

HYD1  -  probable 3-beta-hydroxysteroid-Delta(8)...

Arabidopsis thaliana

Synonyms: HYDRA1, MAD4, miRNA action deficient 4
 
 
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High impact information on HYD1

  • We demonstrate that the HYDRA1 gene encodes a Delta8-Delta7 sterol isomerase, whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL gene product [1].
  • Comprehensive gas chromatography GC-MS analysis of hyd1 in comparison to fk reveals an abnormal accumulation of unique sterol intermediates in each case [2].
  • Previous evidence shows that two sterol-defective mutants of Arabidopsis thaliana (L.) Heynh., hyd1 and fk(hyd2), are defective in root development [3].
  • This supports the emerging view that the hyd1 and fk(hyd2) mutants exhibit an enhanced and unregulated ethylene signalling activity, which accounts for at least part of the observed mutant phenotypes, including disrupted auxin signalling [3].
  • The patterns of cell division during early stages of lateral root initiation in the hyd1 and fk(hyd2) mutants appear normal [3].
 

Other interactions of HYD1

  • Our experiments reveal that FK and HYD1 act sequentially, whereas CPH acts independently of these genes to produce essential sterols [4].

References

  1. hydra Mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling. Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., Grierson, D., Lindsey, K. Plant Cell (2002) [Pubmed]
  2. A link between sterol biosynthesis, the cell wall, and cellulose in Arabidopsis. Schrick, K., Fujioka, S., Takatsuto, S., Stierhof, Y.D., Stransky, H., Yoshida, S., Jürgens, G. Plant J. (2004) [Pubmed]
  3. Rescue of defective auxin-mediated gene expression and root meristem function by inhibition of ethylene signalling in sterol biosynthesis mutants of Arabidopsis. Souter, M.A., Pullen, M.L., Topping, J.F., Zhang, X., Lindsey, K. Planta (2004) [Pubmed]
  4. Interactions between sterol biosynthesis genes in embryonic development of Arabidopsis. Schrick, K., Mayer, U., Martin, G., Bellini, C., Kuhnt, C., Schmidt, J., Jürgens, G. Plant J. (2002) [Pubmed]
 
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