Gene Review:
IAR4 - pyruvate dehydrogenase E1 component...
Arabidopsis thaliana
Synonyms:
F3I6.11, F3I6_11, IAA-CONJUGATE-RESISTANT 4
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High impact information on IAR4
- IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog [1].
- We did not detect glycolysis or Krebs-cycle-related defects in the iar4 mutant, and a T-DNA insertion in the IAR4 coding sequence conferred similar phenotypes as the originally identified missense allele [1].
- It is possible that IAR4 acts in the conversion of indole-3-pyruvate to indole-3-acetyl-coenzyme A, which is a potential precursor of IAA and IAA conjugates [1].
- The gene defective in iar4 encodes a homolog of the E1alpha-subunit of mitochondrial pyruvate dehydrogenase, which converts pyruvate to acetyl-coenzyme A [1].
Associations of IAR4 with chemical compounds
- Here we report the isolation and characterization of the Arabidopsis iar4 mutant, which has reduced sensitivity to several IAA-amino acid conjugates. iar4 is less sensitive to a synthetic auxin and low concentrations of an ethylene precursor but responds to free IAA and other hormones tested similarly to wild type [1].
References
- IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. LeClere, S., Rampey, R.A., Bartel, B. Plant Physiol. (2004) [Pubmed]
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