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Gene Review

VIP1  -  VIRE2-interacting protein 1

Arabidopsis thaliana

Synonyms: F2J6.6, F2J6_6, SUE3, VIRE2-INTERACTING PROTEIN, sulphate utilization efficiency 3
 
 
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Disease relevance of VIP1

 

High impact information on VIP1

  • As VIP1 is not an abundant protein, representing one of the limiting factors for transformation, Agrobacterium may have evolved to produce and export to the host cells its own virulence protein that at least partially complements the cellular VIP1 function necessary for the T-DNA nuclear import and subsequent expression within the infected cell [2].
  • Our data indicate that VirE3 can mimic this VIP1 function, acting as an 'adapter' molecule between VirE2 and karyopherin alpha and 'piggy-backing' VirE2 into the host cell nucleus [2].
 

Biological context of VIP1

  • The identified plant protein, designated VIP1, specifically bound VirE2 and allowed its nuclear import in non-plant systems [3].
  • During this process, Agrobacterium exports its transferred (T) DNA and several virulence (Vir) proteins into the host cell, within which T-DNA nuclear import is mediated by VirD2 (ref. 3) and VirE2 (ref. 4) and their host cell interactors AtKAP-alpha and VIP1 (ref. 6), whereas its integration is mediated mainly by host cell proteins [4].
 

Anatomical context of VIP1

  • One such cellular factor is VIP1, an Arabidopsis protein proposed to interact with and facilitate import of the bacterial DNA-protein transport (T) complexes into the plant cell nucleus [1].

References

 
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