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PEN3  -  ABC transporter G family member 36

Arabidopsis thaliana

Synonyms: ABCG36, ARABIDOPSIS PLEIOTROPIC DRUG RESISTANCE 8, ARABIDOPSIS THALIANA ATP-BINDING CASSETTE G36, ATABCG36, ATP-BINDING CASSETTE G36, ...
 
 
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High impact information on PDR8/PEN3

  • PEN3/PDR8 tagged with green fluorescent protein localized to the plasma membrane in uninfected cells [1].
  • The phenotypes conferred by pen3 result from the loss of function of PLEIOTROPIC DRUG RESISTANCE8 (PDR8), a highly expressed putative ATP binding cassette transporter [1].
  • PEN3/PDR8 may be involved in exporting toxic materials to attempted invasion sites, and intracellular accumulation of these toxins in pen3 may secondarily activate the salicylic acid pathway [1].
  • Our results indicate that AtPDR8 is a key factor controlling the extent of cell death in the defense response and suggest that AtPDR8 transports some substance(s) which is closely related to the response of plants to pathogens [2].
  • Loss of AtPDR8, a Plasma Membrane ABC Transporter of Arabidopsis thaliana, Causes Hypersensitive Cell Death Upon Pathogen Infection [2].
 

Biological context of PDR8/PEN3

  • When a knockout mutant of AtPDR8 (atpdr8) was infected with bacterial and oomycete pathogens, the plants exhibited chlorotic lesions and a hypersensitive response (HR)-like cell death [2].
 

Anatomical context of PDR8/PEN3

 

Analytical, diagnostic and therapeutic context of PDR8/PEN3

  • In the stomata, transcripts of AtPDR8 were particularly frequent in the cells surrounding air spaces [2].

References

  1. Arabidopsis PEN3/PDR8, an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration. Stein, M., Dittgen, J., Sánchez-Rodríguez, C., Hou, B.H., Molina, A., Schulze-Lefert, P., Lipka, V., Somerville, S. Plant Cell (2006) [Pubmed]
  2. Loss of AtPDR8, a Plasma Membrane ABC Transporter of Arabidopsis thaliana, Causes Hypersensitive Cell Death Upon Pathogen Infection. Kobae, Y., Sekino, T., Yoshioka, H., Nakagawa, T., Martinoia, E., Maeshima, M. Plant Cell Physiol. (2006) [Pubmed]
 
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