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Gene Review: 

RPN12a  -  26S proteasome non-ATPase regulatory...

Arabidopsis thaliana

Synonyms: F1N19.9, F1N19_9, regulatory particle non-ATPase 12A
 
 
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High impact information on AT1G64520

  • It is composed of a self-compartmentalized core protease (CP) that houses the peptidase active sites appended on either or both ends by a regulatory particle (RP) that identifies appropriate substrates and translocates them into the lumen of the CP for breakdown [1].
  • The Arabidopsis thaliana genome has over 550 protease sequences representing all five catalytic types: serine, cysteine, aspartic acid, metallo and threonine (MEROPS peptidase database, http://merops.sanger.ac.uk/), which probably reflect a wide variety of as yet unidentified functions performed by plant proteases [2].

References

  1. Purification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms. Yang, P., Fu, H., Walker, J., Papa, C.M., Smalle, J., Ju, Y.M., Vierstra, R.D. J. Biol. Chem. (2004) [Pubmed]
  2. The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis. Beers, E.P., Jones, A.M., Dickerman, A.W. Phytochemistry (2004) [Pubmed]
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