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RNF135  -  ring finger protein 135

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF135, L13, MGC13061, MMFD, REUL, ...
 
 
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Disease relevance of RNF135

 

High impact information on RNF135

  • However, access to this dimetal site is blocked by a pair of hydrophobic leucine residues (L13 and L13'), which prevent facile entry of metal ions and small molecules [3].
  • Spin inversion transfer experiments are reported bearing on the thermodynamics and kinetics of interconversion of the two dimeric folded forms (Fa <--> Fb) at the 13Calpha-labeled position L13 [4].
  • In the tandem L13 mini-gene system, the L1URE is revealed to influence steady state mRNA stability, and subdomains within L1URE influence both gene expression and the steady state ratio of transcripts processed at proximal versus distal poly (A) sites [5].
  • The first mutation disrupts a base pair in the transcription terminator stem for the rplM-rpsI operon, which encodes ribosomal proteins L13 and S9 [6].
  • The QLQ-C30 and L13 subscales showed greater improvement in the gemcitabine plus BSC arm (in 11 domains) than in the BSC arm (one symptom item) [7].
 

Biological context of RNF135

  • The hydrolysis of terminal (t)butyl-ester groups provides the novel nonadentate podand tris[2-[N-methylcarbamoyl-(6-carboxypyridine-2)-ethyl]amine] (L13) which exists as a mixture of slowly interconverting conformers in solution [8].
  • Knocking down L13 expression using small interfering RNA (siRNA) resulted in drastic attenuation of cancer cell growth with significant G1 and G2/M arrest of the cell cycle [2].
 

Anatomical context of RNF135

  • In our study, affinity resin L13, which reduces brain-derived infectivity spiked into human red blood cell concentrate by around 4 log(10)ID(50), and its equivalent, L13A, produced on a manufacturing scale, were assessed for their ability to remove TSE infectivity endogenously present in blood [9].
  • In addition, L13 fetuses were injected--directly into the amniotic sac--with 0.1 mg DBCP [10].
 

Associations of RNF135 with chemical compounds

  • In the cases of mutation of R18G, D19A, or K2Q and the conversion to proline of L9, L13, V17, or A20, no products were detected in transfected cells [11].
 

Other interactions of RNF135

 

Analytical, diagnostic and therapeutic context of RNF135

  • By using semiquantitative RT-PCR, we analyzed expression of L13 in freshly resected cancer tissue of the stomach, colorectum and liver [2].

References

  1. Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas. Chuman, Y., Sumizawa, T., Takebayashi, Y., Niwa, K., Yamada, K., Haraguchi, M., Furukawa, T., Akiyama, S., Aikou, T. Int. J. Cancer (1996) [Pubmed]
  2. Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. Kobayashi, T., Sasaki, Y., Oshima, Y., Yamamoto, H., Mita, H., Suzuki, H., Toyota, M., Tokino, T., Itoh, F., Imai, K., Shinomura, Y. Int. J. Mol. Med. (2006) [Pubmed]
  3. Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. Di Costanzo, L., Wade, H., Geremia, S., Randaccio, L., Pavone, V., DeGrado, W.F., Lombardi, A. J. Am. Chem. Soc. (2001) [Pubmed]
  4. Site-specific thermodynamics and kinetics of a coiled-coil transition by spin inversion transfer NMR. d'Avignon, D.A., Bretthorst, G.L., Holtzer, M.E., Holtzer, A. Biophys. J. (1998) [Pubmed]
  5. Characterization of an upstream regulatory element of adenovirus L1 poly (A) site. Liu, L. Virology (2005) [Pubmed]
  6. Temperature sensitivity caused by mutant release factor 1 is suppressed by mutations that affect 16S rRNA maturation. Kaczanowska, M., Rydén-Aulin, M. J. Bacteriol. (2004) [Pubmed]
  7. Gemcitabine plus best supportive care (BSC) vs BSC in inoperable non-small cell lung cancer--a randomized trial with quality of life as the primary outcome. UK NSCLC Gemcitabine Group. Non-Small Cell Lung Cancer. Anderson, H., Hopwood, P., Stephens, R.J., Thatcher, N., Cottier, B., Nicholson, M., Milroy, R., Maughan, T.S., Falk, S.J., Bond, M.G., Burt, P.A., Connolly, C.K., McIllmurray, M.B., Carmichael, J. Br. J. Cancer (2000) [Pubmed]
  8. Connecting terminal carboxylate groups in nine-coordinate lanthanide podates: consequences on the thermodynamic, structural, electronic, and photophysical properties. Senegas, J.M., Bernardinelli, G., Imbert, D., Bünzli, J.C., Morgantini, P.Y., Weber, J., Piguet, C. Inorganic chemistry. (2003) [Pubmed]
  9. Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins. Gregori, L., Gurgel, P.V., Lathrop, J.T., Edwardson, P., Lambert, B.C., Carbonell, R.G., Burton, S.J., Hammond, D.J., Rohwer, R.G. Lancet (2007) [Pubmed]
  10. Reproductive performance of dibromochloropropane-treated female rats. Shaked, I., Sod-Moriah, U.A., Kaplanski, J., Potashnik, G., Buchman, O. Int. J. Fertil. (1988) [Pubmed]
  11. Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase. Mizuno, T., Ito, K., Uchida, C., Kitagawa, M., Ichiyama, A., Miura, S., Fujita, K., Oda, T. Histochem. Cell Biol. (2002) [Pubmed]
  12. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. Oshiumi, H., Matsumoto, M., Hatakeyama, S., Seya, T. J. Biol. Chem. (2009) [Pubmed]
 
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