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Gene Review

CAPNS2  -  calpain, small subunit 2

Homo sapiens

Synonyms: CSS2, Calcium-dependent protease small subunit 2, Calpain small subunit 2, MGC12536, MGC14804
 
 
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Disease relevance of CAPNS2

 

High impact information on CAPNS2

  • Here we report the identification, cloning and characterization of a novel human small subunit (css2) encoded by an intronless gene, capns2, located on chromosome 16 [2].
  • Computer-based homology modeling was used to predict interactions between the traditional small subunit (css1) or css2 with the 80 kDa catalytic subunit [1].
  • Casein zymography was used to measure the enzymatic activity of 80 kDa/css2 proteins [1].
 

Analytical, diagnostic and therapeutic context of CAPNS2

  • METHODS: Tissues from rat, monkey, and man of various ages were used to determine expression patterns of css2 by relative quantitative RT-PCR using 18S rRNA as an endogenous standard [1].

References

  1. Expression of calpain small subunit 2 in mammalian tissues. Ma, H., Nakajima, E., Shih, M., Azuma, M., Shearer, T.R. Curr. Eye Res. (2004) [Pubmed]
  2. A novel human small subunit of calpains. Schád, E., Farkas, A., Jékely, G., Tompa, P., Friedrich, P. Biochem. J. (2002) [Pubmed]
 
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