The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

GAD2  -  glutamate decarboxylase 2

Arabidopsis thaliana

Synonyms: F12P19.12, F12P19_12, GLUTAMATE DECARBOXYLASE 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of GAD2

 

High impact information on GAD2

  • The enzymatic activities of the pure recombinant GAD1 and GAD2 proteins were stimulated 35- and 13-fold, respectively, by Ca2+/calmodulin but not by Ca2+ or calmodulin alone [1].
  • The specific activity, GAD2 transcript, and 56-kD peptide increased in leaves of plants treated with 10 mM NH4Cl, 5 mM NH4NO3, 5 mM glutamic acid, or 5 mM glutamine as the sole nitrogen source compared with samples from plants treated with 10 mM KNO3 [1].
  • In addition, a putative EF-hand loop, shown to be associated with Ca2+ binding, was identified in the GDH2 gene product but not in the GDH1 gene product [3].
  • The nucleotide sequences of cDNAs encoding two isoforms of Arabidopsis glutamate decarboxylase, designated GAD1 (57.1 kDa) and GAD2 (56.1 kDa) and sharing 82% identical amino acid sequences, were determined [2].
 

Regulatory relationships of GAD2

  • Northern hybridization and western blot analysis revealed that GAD1 was expressed only in roots and GAD2 in roots, leaves, inflorescence stems and flowers [2].
 

Other interactions of GAD2

  • Analysis of the recombinant proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblot analysis suggest that GAD1 and GAD2 encode for 58- and 56-kD peptides, respectively [1].

References

  1. Characterization of two glutamate decarboxylase cDNA clones from Arabidopsis. Turano, F.J., Fang, T.K. Plant Physiol. (1998) [Pubmed]
  2. Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution. Zik, M., Arazi, T., Snedden, W.A., Fromm, H. Plant Mol. Biol. (1998) [Pubmed]
  3. Characterization and expression of NAD(H)-dependent glutamate dehydrogenase genes in Arabidopsis. Turano, F.J., Thakkar, S.S., Fang, T., Weisemann, J.M. Plant Physiol. (1997) [Pubmed]
 
WikiGenes - Universities