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Gene Review:

Trpc4 - transient receptor potential cation...

Rattus norvegicus

Synonyms: CCE1, Capacitative calcium entry channel 1, Short transient receptor potential channel 4, Trp4, TrpC4, ...

Rovero, P. et al., Poburko, D. et al.

Poburko, Lhote, Szado, Behra, Rahimian, McManus, van Breemen, Ruegg,

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High impact information on Trpc4

Asp2, Trp4 and the C-terminal glycinamide have been challenged by classical amino acid substitutions with the aim of elucidating the structural requirements responsible for NK2 subtype selectivity [1].

Analytical, diagnostic and therapeutic context of Trpc4

Reverse transcriptase polymerase chain reaction revealed TrpC1, 4 and 6 mRNA, and we propose that 2-APB may selectively block TrpC4-containing channels [2].

References

Structure-activity relationship study of R396, an NK2 tachykinin antagonist selective for the NK2B receptor subtype. Rovero, P., Astolfi, M., Manzini, S., Jukic, D., Rouissi, N., Maggi, C.A., Regoli, D. Neuropeptides (1992) [Pubmed]
Basal calcium entry in vascular smooth muscle. Poburko, D., Lhote, P., Szado, T., Behra, T., Rahimian, R., McManus, B., van Breemen, C., Ruegg, U.T. Eur. J. Pharmacol. (2004) [Pubmed]

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