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Gene Review

Srm  -  spermidine synthase

Rattus norvegicus

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Disease relevance of Srm


High impact information on Srm


Biological context of Srm


Associations of Srm with chemical compounds


Other interactions of Srm


Analytical, diagnostic and therapeutic context of Srm


  1. Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells. Feuerstein, B.G., Deen, D.F., Marton, L.J. Cancer Res. (1985) [Pubmed]
  2. Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases. Beppu, T., Shirahata, A., Takahashi, N., Hosoda, H., Samejima, K. J. Biochem. (1995) [Pubmed]
  3. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Woster, P.M., Black, A.Y., Duff, K.J., Coward, J.K., Pegg, A.E. J. Med. Chem. (1989) [Pubmed]
  4. Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine. Della Ragione, F., Pegg, A.E. Biochem. J. (1983) [Pubmed]
  5. Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. Pegg, A.E., Tang, K.C., Coward, J.K. Biochemistry (1982) [Pubmed]
  6. 2-Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells. Hibasami, H., Kawase, M., Tsukada, T., Maekawa, S., Sakurai, M., Nakashima, K. FEBS Lett. (1988) [Pubmed]
  7. Enzymatic aminopropylation of certain secondary amines. Shirahata, A., Hosoda, H., Takahashi, N., Beppu, T., Niitsu, M., Samejima, K. Biol. Pharm. Bull. (1995) [Pubmed]
  8. Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. Dejima, H., Kobayashi, M., Takasaki, H., Takeda, N., Shirahata, A., Samejima, K. Biol. Pharm. Bull. (2003) [Pubmed]
  9. Dicyclohexylamine, a potent inhibitor of spermidine synthase in mammalian cells. Hibasami, H., Tanaka, M., Nagai, J., Ikeda, T. FEBS Lett. (1980) [Pubmed]
  10. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Shirahata, A., Takahashi, N., Beppu, T., Hosoda, H., Samejima, K. Biochem. Pharmacol. (1993) [Pubmed]
  11. Methylglyoxal bis(butylamidinohydrazone), a new inhibitor of polyamine biosynthesis that simultaneously inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase. Hibasami, H., Tsukada, T., Maekawa, S., Nakashima, K. Biochem. Pharmacol. (1986) [Pubmed]
  12. Regulation of S-adenosyl-L-methionine decarboxylase by 1-aminooxy-3-aminopropane: enzyme kinetics and effects on the enzyme activity in cultured cells. Hyvönen, T., Eloranta, T.O. J. Biochem. (1990) [Pubmed]
  13. Purification of spermidine synthase from rat ventral prostate by affinity chromatography on immobilized S-adenosyl(5')-3-thiopropylamine. Samejima, K., Yamanoha, B. Arch. Biochem. Biophys. (1982) [Pubmed]
  14. Control of spermidine and spermine levels in rat tissues by trans-4-methylcyclohexylamine, a spermidine-synthase inhibitor. Kobayashi, M., Watanabe, T., Xu, Y.J., Tatemori, M., Goda, H., Niitsu, M., Shirahata, A., Samejima, K. Biol. Pharm. Bull. (2005) [Pubmed]
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