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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

ST11  -  suppression of tumorigenicity 11 (pancreas)

Homo sapiens

Synonyms: PETS1
 
 
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Disease relevance of ST11

  • Clusters of meningococcal disease caused by a hyperinvasive lineage of Neisseria meningitidis, the ST11 complex, bearing a serogroup C polysaccharide capsule, have been prominent in Europe and North America since the early 1990s [1].
  • We investigated whether regular ingestion of a dietary product containing Lactobacillus johnsonii La1 or L. paracasei ST11 would interfere with H. pylori colonization in children [2].
  • RESULTS: No effect of ST11 treatment on severe rotavirus diarrhea was observed [3].
  • Molecular epidemiology of neisseria meningitidis isolated in the African Meningitis Belt between 1988 and 2003 shows dominance of sequence type 5 (ST-5) and ST-11 complexes [4].
  • In Niamey, only sporadic cases were reported: 55% of the meningococcus strains were in serogroup A, and 38% were in serogroup W135 and could be placed in ST-11, identical to the 2002 Burkina Faso epidemic clone, and in ST-2881, a new ST [5].
 

High impact information on ST11

  • Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America [1].
  • The rate of capsule gene expression did not vary with age of carrier or meningococcal genotype, except for serogroup C, for which increased expression was associated with ST-11 (formerly ET-37) complex meningococci [6].
  • The method might be especially valuable for differentiating among ST-11 strains, as shown by the VNTR analyses of serogroup W135 ST-11 meningococcal isolates recovered since the mid-1990s [7].
  • However, serogroup B and C, ET37/ST-11 isolates both express similar virulence as assessed from colonization and invasiveness in a mouse model [8].
  • There were several vaccination campaigns against serogroup C in France in 2002, following an increase in the prevalence of invasive isolates of serogroup C of the phenotype C:2a:P1.5 and C:2a:P1.5,2 belonging to the ET-37/ST-11 clonal complex [8].
 

Biological context of ST11

  • These data confirm the changing epidemiology of meningococcal infection in Burkina Faso with the establishment and expansion of serogroup W135 N. meningitidis strains of the ET-37/ST-11 clonal complex, as well as the emergence of a new clone within the subgroup III/ST-5 clonal complex [9].
  • SNP sets that are diagnostic for Neisseria meningitidis ST-11 and ST-42, and high-D SNP sets for N. meningitidis and Staphylococcus aureus, were identified and real-time PCR methods to interrogate these SNPs were demonstrated [10].
 

Associations of ST11 with chemical compounds

 

Analytical, diagnostic and therapeutic context of ST11

  • Subjects were 326 asymptomatic children (9.7 +/- 2.6 y) screened for H. pylori by the (13)C-urea breath test; H. pylori-colonized subjects were distributed into five groups to receive a product containing live La1 or ST11 (groups 1 and 3), heat-killed La1 or ST11 (groups 2 and 4), or vehicle (group 5) everyday for 4 wk [2].
  • Molecular epidemiology of meningococci isolated in Niger in 2003 shows serogroup A sequence type (ST)-7 and serogroup W135 ST-11 or ST-2881 strains [5].
  • Using PCR primers specific for the LT I and ST II genes, a multiplex PCR system which allows detection of LT 1-and ST 11-producing ETEC strains was developed [11].
  • W135 (ST-11) isolates involved in meningitis outbreaks in Burkina Faso differed from those involved in the Hajj-2000 associated outbreak by their pulsed-field gel electrophoresis profile [9].

References

  1. Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America. Pollard, A.J., Ochnio, J., Ho, M., Callaghan, M., Bigham, M., Dobsong, S. Emerging Infect. Dis. (2004) [Pubmed]
  2. Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. Cruchet, S., Obregon, M.C., Salazar, G., Diaz, E., Gotteland, M. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  3. Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh. Sarker, S.A., Sultana, S., Fuchs, G.J., Alam, N.H., Azim, T., Brüssow, H., Hammarström, L. Pediatrics (2005) [Pubmed]
  4. Molecular epidemiology of neisseria meningitidis isolated in the African Meningitis Belt between 1988 and 2003 shows dominance of sequence type 5 (ST-5) and ST-11 complexes. Nicolas, P., Norheim, G., Garnotel, E., Djibo, S., Caugant, D.A. J. Clin. Microbiol. (2005) [Pubmed]
  5. Molecular epidemiology of meningococci isolated in Niger in 2003 shows serogroup A sequence type (ST)-7 and serogroup W135 ST-11 or ST-2881 strains. Nicolas, P., Djibo, S., Moussa, A., Tenebray, B., Boisier, P., Chanteau, S. J. Clin. Microbiol. (2005) [Pubmed]
  6. Genetic analysis of meningococci carried by children and young adults. Claus, H., Maiden, M.C., Wilson, D.J., McCarthy, N.D., Jolley, K.A., Urwin, R., Hessler, F., Frosch, M., Vogel, U. J. Infect. Dis. (2005) [Pubmed]
  7. Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitidis. Yazdankhah, S.P., Lindstedt, B.A., Caugant, D.A. J. Clin. Microbiol. (2005) [Pubmed]
  8. Conserved virulence of C to B capsule switched Neisseria meningitidis clinical isolates belonging to ET-37/ST-11 clonal complex. Lancellotti, M., Guiyoule, A., Ruckly, C., Hong, E., Alonso, J.M., Taha, M.K. Microbes Infect. (2006) [Pubmed]
  9. The establishment of Neisseria meningitidis serogroup W135 of the clonal complex ET-37/ST-11 as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso. Njanpop-Lafourcade, B.M., Parent du Châtelet, I., Sanou, O., Alonso, J.M., Taha, M.K. Microbes Infect. (2005) [Pubmed]
  10. Identification and interrogation of highly informative single nucleotide polymorphism sets defined by bacterial multilocus sequence typing databases. Robertson, G.A., Thiruvenkataswamy, V., Shilling, H., Price, E.P., Huygens, F., Henskens, F.A., Giffard, P.M. J. Med. Microbiol. (2004) [Pubmed]
  11. Use of a multiplex PCR system for the simultaneous detection of heat labile toxin I and heat stable toxin II genes of enterotoxigenic Escherichia coil in skim milk and porcine stool. Tsen, H.Y., Jian, L.Z., Chi, W.R. J. Food Prot. (1998) [Pubmed]
 
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