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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CARD6  -  caspase recruitment domain family, member 6

Homo sapiens

Synonyms: CINCIN1, Caspase recruitment domain-containing protein 6
 
 
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High impact information on CARD6

  • Importantly, CARD6 expression has a synergistic effect on NF-kappaB activation induced by several independent signal transduction pathways [1].
  • Cardiak and Nod1 (but not other CARD proteins) also exhibited opposing effects on CARD6 protein phosphorylation and expression, providing further evidence of functional interactions among these proteins in cells [2].
  • We cloned a novel cDNA derived from the CARD6 gene locus on chromosome 5p12 of 311 amino acids in length [2].
  • CARD6 also did not affect caspase activation and apoptosis induced by overexpression of Fas, Bax, or other pro-apoptotic stimuli [2].
  • CARD tricks: controlling the interactions of CARD6 with RICK and microtubules [3].

References

  1. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. Dufner, A., Pownall, S., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. Stehlik, C., Hayashi, H., Pio, F., Godzik, A., Reed, J.C. J. Biol. Chem. (2003) [Pubmed]
  3. CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. Dufner, A., Mak, T.W. Cell Cycle (2006) [Pubmed]
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