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Gene Review

ZNF496  -  zinc finger protein 496

Homo sapiens

Synonyms: MGC15548, NIZP1, ZFP496, ZKSCAN17, ZSCAN49, ...
 
 
 
 
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High impact information on ZNF496

  • Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif [1].
  • Mutations of the cysteine or histidine residues in the C2HR motif abolish the interaction of Nizp1 with NSD1 and compromise the ability of Nizp1 to repress transcription [1].
 

Biological context of ZNF496

  • Thus, Nizp1 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif [1].

References

  1. Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif. Nielsen, A.L., Jørgensen, P., Lerouge, T., Cerviño, M., Chambon, P., Losson, R. Mol. Cell. Biol. (2004) [Pubmed]
 
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