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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SOF1  -  Sof1p

Saccharomyces cerevisiae S288c

Synonyms: L1339, Protein SOF1, U3 small nucleolar RNA-associated protein SOF1, U3 snoRNA-associated protein SOF1, YLL011W
 
 
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High impact information on SOF1

  • Thus, SOF1 is a new component of the nucleolar rRNA processing machinery [1].
  • In its central domain, SOF1 contains a repeated sequence also found in beta-subunits of trimeric G-proteins and the splicing factor PRP4 [1].
  • The wild-type allele of SOF1 is essential for cell growth and encodes a novel 56 kDa protein [1].
  • Finally, we found that an overall reduction in the levels of box C/D snoRNPs by genetic depletion of the common Nop58p protein did not affect coprecipitation of 35S pre-rRNA by Sof1p [2].
  • Sof1p is a trans-acting protein that is essential for biogenesis of the 40S ribosomal subunits in the yeast Saccharomyces cerevisiae [2].
 

Biological context of SOF1

 

Analytical, diagnostic and therapeutic context of SOF1

References

  1. A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. Jansen, R., Tollervey, D., Hurt, E.C. EMBO J. (1993) [Pubmed]
  2. Saccharomyces cerevisiae Sof1p associates with 35S Pre-rRNA independent from U3 snoRNA and Rrp5p. Bax, R., Vos, H.R., Raué, H.A., Vos, J.C. Eukaryotic Cell (2006) [Pubmed]
  3. Characterization of karyopherin cargoes reveals unique mechanisms of Kap121p-mediated nuclear import. Leslie, D.M., Zhang, W., Timney, B.L., Chait, B.T., Rout, M.P., Wozniak, R.W., Aitchison, J.D. Mol. Cell. Biol. (2004) [Pubmed]
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