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MMM1  -  Mmm1p

Saccharomyces cerevisiae S288c

Synonyms: L1357, Maintenance of mitochondrial morphology protein 1, Mitochondrial outer membrane protein MMM1, YLL006W, YME6, ...
 
 
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High impact information on MMM1

  • MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria [1].
  • In contrast, deletion of MMM1 resulted in mislocalization of Mdm12p, and deletion of MDM12 caused mislocalization of Mmm1p [2].
  • We report the cloning and characterization of MMM1 of the filamentous fungus Neurospora crassa, an organism that uses microtubules for mitochondrial transport [3].
  • The MMM1 protein has a single transmembrane domain near the N terminus and exposes a large C-terminal domain to the cytosol [3].
  • A dominant suppressor also suppresses the phenotypes caused by a point mutation in MMM1, as well as by specific mutations in YME4 and MDM10 [4].
 

Biological context of MMM1

  • While the other yme mutations had no detectable growth phenotypes, synergistic interactions were observed in two double mutant combinations: a yme1, yme2 double mutant failed to respire at 30 degrees and a yme4, yme6 double mutant failed to respire at all temperatures tested [5].
 

Anatomical context of MMM1

 

Other interactions of MMM1

  • All 21 mutations were recessive and fell into six complementation groups, termed YME1-YME6 [5].

References

  1. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. Burgess, S.M., Delannoy, M., Jensen, R.E. J. Cell Biol. (1994) [Pubmed]
  2. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Boldogh, I.R., Nowakowski, D.W., Yang, H.C., Chung, H., Karmon, S., Royes, P., Pon, L.A. Mol. Biol. Cell (2003) [Pubmed]
  3. Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa. Prokisch, H., Neupert, W., Westermann, B. Mol. Biol. Cell (2000) [Pubmed]
  4. Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Hanekamp, T., Thorsness, M.K., Rebbapragada, I., Fisher, E.M., Seebart, C., Darland, M.R., Coxbill, J.A., Updike, D.L., Thorsness, P.E. Genetics (2002) [Pubmed]
  5. Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Thorsness, P.E., Fox, T.D. Genetics (1993) [Pubmed]
 
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