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Gene Review: 

SRN2  -  ESCRT-I subunit protein SRN2

Saccharomyces cerevisiae S288c

Synonyms: ESCRT-I complex subunit VPS37, L2958, L9233.5, Protein SRN2, SRN10, ...
 
 
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High impact information on SRN2

  • In addition, we characterize a 350 kDa complex, ESCRT-I (composed of Vps23, Vps28, and Vps37), that recognizes ubiquitinated MVB cargo and whose function is required for sorting into MVB vesicles [1].
  • A region of the yeast genome (SRN2) is described that suppresses temperature-sensitive rna2 mutations when it is present on either medium or high-copy number plasmids [2].
  • Two-hybrid analysis reveals that there is a physical interaction between Srn10p and Rna1p in vivo [3].
  • The SRN10 gene is not essential for cell viability and encodes an acidic protein (pI = 5.27) of 24.8 kDa [3].
 

Biological context of SRN2

 

Analytical, diagnostic and therapeutic context of SRN2

References

  1. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Katzmann, D.J., Babst, M., Emr, S.D. Cell (2001) [Pubmed]
  2. Evidence for related functions of the RNA genes of Saccharomyces cerevisiae. Last, R.L., Maddock, J.R., Woolford, J.L. Genetics (1987) [Pubmed]
  3. Isolation of an extragenic suppressor of the rna1-1 mutation in Saccharomyces cerevisiae. Hong, S.J., Yi, Y.S., Koh, S.S., Park, O.K., Kang, H.S. Mol. Gen. Genet. (1998) [Pubmed]
  4. Efficient Cargo Sorting by ESCRT-I and the Subsequent Release of ESCRT-I from Multivesicular Bodies Requires the Subunit Mvb12. Curtiss, M., Jones, C., Babst, M. Mol. Biol. Cell (2007) [Pubmed]
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